Protein NFKBIZ map

Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:MIRNA_TF_IMMUNOSTIMULATORY

References
CASCADE:IL18
 NATURAL_KILLER  map
PMID:20876105
NFKBIZ induced by IL18 together with STAT4 induced by IL12 activates IFNG expression in NK cells.
STAT4 was not recruited to the Ifng gene regions in Nfkbiz−/− NK cells.
NFKBIZ is Required for change in histone 3 lysine 9 acetylation in response to IL-12 and IL-18 in NK Cells.
PMID:21224476
NFKBIZ binds to the IFNG promoter in response to IL-12 and IL-18 and encreases promoter activity.
NFKBIZ regulates IFNG expression by binding to NF-κB p65/p50.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. NFKBIZ@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rNFKBIZ@INNATE_IMMUNE_CELL_Cytosol map → map NFKBIZ@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. gIFNG@INNATE_IMMUNE_CELL_Cytosol map → map rIFNG@INNATE_IMMUNE_CELL_Cytosol map