Protein PAK1 map

Identifiers
HUGO:PAK1

Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS

References
 NATURAL_KILLER  map
CASCADE:NKP46
CASCADE:INTEGRIN_A4B1
CASCADE:INTEGRIN_A5B1
PMID:11062502, PMID:11385609, PMID:11907067, PMID:15536084
Nkp46 controls NK cytolitic activity via PI3K /RAC1/PAK1/MEK /ERK pathway, probably throught SYK
PMID:11907067, PMID:11062502
RAC1 activates PAK1 downstream of SYK and PI3K and upstream of ERK and MEK.
PMID:12885870
Engagement of the beta2 integrin LFA-1 on NK cells by intercellular adhesion molecule (ICAM)-1 led to a tyrosine phosphorylation of Vav1 that was not sensitive to cholesterol depletion and to inhibition of actin polymerization. Vav1 phosphorylation was blocked by an inhibitor of Src-family kinases, and correlated with activation of its downstream effector PAK1.
PMID:10661401
Cross-Linking of β1 Integrins on Human NK Cells via VAV1 activates Rac1, which controls p38 MAPK Activation.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. PAK1@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. PAK1@INNATE_IMMUNE_CELL_Cytosol map → map PAK1@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. MEK*@INNATE_IMMUNE_CELL_Cytosol map → map MEK*|​pho@INNATE_IMMUNE_CELL_Cytosol map
    2. MAP2K3@INNATE_IMMUNE_CELL_Cytosol map → map MAP2K3|​pho@INNATE_IMMUNE_CELL_Cytosol map