Identifiers
HUGO:CD40

Maps_Modules
 DENDRITIC_CELL 
MODULE:MARKERS_DC
MODULE:IMMUNE_STIMULATION
MODULE:IMMUNOSTIMULATORY_CHEKPOINTS
MODULE:EFFECTOR_ACTIVATION
CASCADE:IL3
CASCADE:TLR2_4
CASCADE:TNF
CASCADE:IFNAB

References
PMID:15197224, PMID:7523569, PMID:9359474
The Linkage of Innate to Adaptive Immunity via Maturing Dendritic Cells In Vivo Requires CD40 Ligation in Addition to Antigen Presentation and CD80/86 Costimulation.
PMID:11964292, PMID:14764699
IFNAR signaling upregulates surface expression of CD80, CD86, CD40.Probably via STAT1
PMID:8760829
Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.
PMID: 15034038
IL3 induces CD80, CD86, CD40 surface expression in pDC
PMID: 11207245
I IFN receptor signaling regulates antigen cross-presentation to CD8(+) T cells. (), probably via upregulation of CD80, CD86, CD40, CD83 and MHC class II and CD11c,
PMID:17513775
Probably via STAT1(demondrtated for CD40 and CD11c PMID:14764699, and for CD40, CD80, CD86, and MHC II  )

1. CD40@INNATE_IMMUNE_CELL_Cytosol

1. CD40@INNATE_IMMUNE_CELL_Membrane

1. CD40@MARKERS_DC

1. CD40:​CD40LG@INNATE_IMMUNE_CELL_Membrane

1. CD40@INNATE_IMMUNE_CELL_Cytosol → CD40@INNATE_IMMUNE_CELL_Membrane
2. CD40LG@default + CD40@INNATE_IMMUNE_CELL_Membrane → CD40:​CD40LG@INNATE_IMMUNE_CELL_Membrane
3. CD40@INNATE_IMMUNE_CELL_Membrane → Immune_checkpoints_T_cells_Activators@default

1. CD80@INNATE_IMMUNE_CELL_Cytosol → CD80@INNATE_IMMUNE_CELL_Membrane
2. CD86@INNATE_IMMUNE_CELL_Cytosol → CD86@INNATE_IMMUNE_CELL_Membrane
3. OX40L*@INNATE_IMMUNE_CELL_Cytosol → OX40L*@INNATE_IMMUNE_CELL_Membrane
4. CD70@INNATE_IMMUNE_CELL_Cytosol → CD70@INNATE_IMMUNE_CELL_Membrane