Protein ITGB3
Identifiers
HUGO:ITGB3
Maps_Modules
MODULE:IMMUNE_STIMULATION MODULE:ANTIGEN_PRESENTATION MODULE:EFFECTOR_ACTIVATION MODULE:INPUT_ACTIVATORS MODULE:TUMOR_RECOGNTITON MODULE:INTEGRINS MODULE:DANGER_SIGNAL_PATHWAYS
References
DENDRITIC_CELL
CASCADE:INTEGRIN_AVB3
PMID:9295024, PMID:9763615
Dendritic cells phagocytose apoptotic cells via alphavbeta5, alphavbeta3, and CD36.
The interaction between apoptotic bodies and dendritic cells elicits a rise in intracellular free calcium concentration ([Ca2+]i) which is essential for the process of engulfment.
Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
- ITGAV:ITGB3@INNATE_IMMUNE_CELL_Membrane
- ITGAV:ITGB3:MFGE8:PtdSer@INNATE_IMMUNE_CELL_Membrane
Participates in reactions:
As Reactant or Product:- PtdSer@TUMOR_CELL_AS_INDUCTOR_Membrane
+ MFGE8@TUMOR_CELL_AS_INDUCTOR_Membrane
+ ITGAV:ITGB3@INNATE_IMMUNE_CELL_Membrane
→
ITGAV:ITGB3:MFGE8:PtdSer@INNATE_IMMUNE_CELL_Membrane
- ITGAV:ITGB3:MFGE8:PtdSer@INNATE_IMMUNE_CELL_Membrane
→
EXOCYTOSIS_AND_PHAGOCYTOSIS@INNATE_IMMUNE_CELL_Membrane
As Catalyser:- Tumor_antigen@TUMOR_CELL_AS_EFFECTOR
→
Tumor_antigen@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane