Complex ITGAV:ITGB3:MFGE8:PtdSer map
Complex composition:

  1. ITGAV map
  2. MFGE8 map
  3. ITGB3 map
  4. PtdSer map

ITGAV:​ITGB3:​MFGE8:​PtdSer@INNATE_IMMUNE_CELL_Membrane

Identifiers
NAME:ITGAV:ITGB3:MFGE8:PtdSer

Maps_Modules
MODULE:INPUT_ACTIVATORS MODULE:TUMOR_RECOGNTITON MODULE:INTEGRINS MODULE:DANGER_SIGNAL_PATHWAYS

References
 DENDRITIC_CELL  map
CASCADE:INTEGRIN_AVB3
PMID:22035837, PMID:12000961
The ‘bridging’ molecule MFG-E8 (which binds to PtdSer on apoptotic cells and facilitate engulfment by engaging the integrin αvβ3 on phagocytes (directly demonstrated for macrophages only)

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. ITGAV:​ITGB3:​MFGE8:​PtdSer@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. PtdSer@TUMOR_CELL_AS_INDUCTOR_Membrane map + MFGE8@TUMOR_CELL_AS_INDUCTOR_Membrane map + ITGAV:​ITGB3@INNATE_IMMUNE_CELL_Membrane map → map ITGAV:​ITGB3:​MFGE8:​PtdSer@INNATE_IMMUNE_CELL_Membrane map
  2. ITGAV:​ITGB3:​MFGE8:​PtdSer@INNATE_IMMUNE_CELL_Membrane map → map EXOCYTOSIS_AND_PHAGOCYTOSIS@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. Tumor_antigen@TUMOR_CELL_AS_EFFECTOR map → map Tumor_antigen@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map