Identifiers
HUGO:NFKB2
Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS
References
DENDRITIC_CELL
PMID:23086447
Alternative NFkB pathway induces via phosphorylation of IκB-specific kinase α (IKK-α) the cleavage of p100-RelB to p52-RelB, which then translocates as heterodimer into the nucleus.
Both complete p100 degradation and p100 processing to p52 may occur in Dcs and expression of IKKa, the kinase determining the activity of noncanonical NF-κB pathway, gradually increased during DC differentiation with concomitant p100 processing to p52
PMID:2649237
In macrophages RELB /p52 pathway is associated with M1 polarization ()
→ RELB:p52@INNATE_IMMUNE_CELL_Cytosol
→ NFKB1_p50*:RELA@INNATE_IMMUNE_CELL_Cytosol + p100@INNATE_IMMUNE_CELL_Cytosol
→ NFKB1_p50*:cREL*@INNATE_IMMUNE_CELL_Cytosol + p100@INNATE_IMMUNE_CELL_Cytosol