Complex NFKB1_p50*:RELA map
Complex composition:

  1. NFKB1_p50* map
  2. RELA map

NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol

Identifiers
NAME:NFKB1_p50*:RELA

Maps_Modules
 MACROPHAGE  map
MODULE:CORE_SIGNALING_PATHWAYS
MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS
 NATURAL_KILLER  map
CASCADE:IL2
CASCADE:CSF2
CASCADE:TNF

References
PMID:12133954
IL2R signaling induces IkBa degradation and formation of heterodimeric p50/p65 NFkB complexes
NF-κB binds to the upstream enhancer of the perforin gene and that this pathway is involved in the activation of perforin expression downstream of NFkB
PMID:12759422, PMID:10679398
IL-18 induces NF-κB binding to the IFN-γ gene promoter and induction of gene expression. Probably via NIK pathway.
PMID:21224476, PMID:12759422
NFKBIZ binds to the IFNG promoter in response to IL-12 and IL-18 and encreases promoter activity.
NFKBIZ regulates IFNG expression by bindingof NF-κB p65/p50 on IFNG promoter .

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map → map NFkB*@INNATE_IMMUNE_CELL_Cytosol map
  2. IkB*|​pho:​NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map → map NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map + IkB*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  3. NFKB1_p50*:​RELA:​p100@INNATE_IMMUNE_CELL_Cytosol map → map NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map + p100@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser: