Identifiers
HUGO:MAP3K1
Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS
References
PMID:10465784
ECSIT (evolutionarilyconserved signaling intermediate inToll pathways), is specific for the Toll/IL-1 pathways and is a regulator of MEKK-1 processing. Expression of wild-type ECSIT accelerates processing of MEKK-1, whereas a dominant-negative fragment of ECSIT blocks MEKK-1 processing and activation of NF-κB
ECSIT mutant also strongly inhibited MEKK-1 activation of AP-1 (probably via MAP2K4/JNK),
additionally TRAF6-induced signaling is inhibited by dominant-negative constructs of MEKK-1.
PMID:9582321
DeltaMEKK1 overexpression results in activation of both c-Jun N-terminal kinases/extracellular signal-regulated kinases (JNK/SAPK) and p38 MAPK (non_immune model).
PMID:15170913, PMID:9582321, PMID:11668179
MEKK1 --> SEK1/MKK4 --> p38 mitogen-activated protein kinase pathway upregulates COX2 expression and PGE2 production in macrophages,
via activation of transcription factor C/EBP beta.
PMID:9379049
MKK3 and MKK4 are capable of phosphorylating p38mapk in macrophages,
downstream of TNF/Tnf receptor signaling.
PMID:12048245
IFN-γ-Induced Gene Expression is MEKK1/p38 dependent and MEKK1/ERK dependent
MEKK1 upregulates CEBPB activation via ERK