Complex 2B4*:3BP2*:CD48:SH2D1A map
Complex composition:

  1. 2B4* map
  2. SH2D1A map
  3. CD48 map
  4. 3BP2* map

2B4*|​pho:​3BP2*|​pho:​CD48:​SH2D1A@INNATE_IMMUNE_CELL_Membrane

Identifiers
NAME:2B4*:3BP2*:CD48:SH2D1A

Maps_Modules
MODULE:INPUT_ACTIVATORS MODULE:TUMOR_RECOGNTITON MODULE:NK_ACTIVATING_RECEPTORS

References
CASCADE:KLRB1
CASCADE:KIR2DL1
CASCADE:KIR2DL4
CASCADE:2B4
 NATURAL_KILLER  map
PMID:10358138
Phosphorylated h2B4 recruits SH2D1A (SAP).
Association of SAP with h2B4 prevents recruitment of PTPN11 (SHP-2).
PMID:15169881, PMID:22683124
2B4 signaling induces phosphorylation of SHIP1,VAV1( (probably via LCP2),CBL.
This phosphorylation is dependent on SAP and FYN.
2B4-evoked tyrosine phosphorylation of Vav-1 was nearly abolished in SAP-deficient and SAP R78A NK cells

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. 2B4*|​pho:​3BP2*|​pho:​CD48:​SH2D1A@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. 2B4*|​pho:​CD48:​SH2D1A@INNATE_IMMUNE_CELL_Membrane map + 3BP2*|​pho@INNATE_IMMUNE_CELL_Membrane map → map 2B4*|​pho:​3BP2*|​pho:​CD48:​SH2D1A@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. LCP2@INNATE_IMMUNE_CELL_Cytosol map → map LCP2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  2. PLCG2@INNATE_IMMUNE_CELL_Cytosol map → map PLCG2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  3. PLCG1@INNATE_IMMUNE_CELL_Cytosol map → map PLCG1|​pho@INNATE_IMMUNE_CELL_Cytosol map
  4. CBL@INNATE_IMMUNE_CELL_Cytosol map → map CBL|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  5. LAT|​pho@INNATE_IMMUNE_CELL_Cytosol map → map LAT@INNATE_IMMUNE_CELL_Cytosol map
  6. gFASL*@INNATE_IMMUNE_CELL_Cytosol map → map rFASL*@INNATE_IMMUNE_CELL_Cytosol map