Complex MSH2:MSH6 map
Complex composition:

  1. MSH2 map
  2. MSH6 map

MSH2|​pho:​MSH6|​pho@default

Identifiers
NAME:MSH2:MSH6

Maps_Modules
 dnarepair  map
 dnarepair  map

References
d_re36( dnarepair  map ):
PMID:16332722
Auto-phosphorylation of ATM in response to DNA DSB:
PMID:17303408, PMID:12556884, PMID:16858402
Amplification of ATM auto-phosphorylation by the complex ATM:MRNcomplex:H2AX:MDC1CDK5 phosphorylates and activates ATM
PMID:19151707
d_re37( dnarepair  map ):
PMID:16332722, PMID:15136767
ATR binds stalled fork and phosphorylates CHK1 that activates checkpoint, stops cell cycle
d_re260( dnarepair  map ):
DNA with O6-methylguanine adducts, MutSalpha and MutLalpha activate ATR/ATRIP and BER pathways performs the repair:
PMID:16713580, PMID:18543256
Damaged DNA triggers ATR/ATRIP complex activation
d_re441:( dnarepair  map ) reactionType:is.a

Confidence
REF=5 FUNC=5

Modifications:
Participates in complexes:
In compartment: default
  1. MSH2|​pho:​MSH6|​pho@default map
Participates in reactions:
As Reactant or Product:
  1. MSH2|​pho@default map + MSH6|​pho@default map → map MSH2|​pho:​MSH6|​pho@default map
  2. MSH2|​pho:​MSH6|​pho@default map → map d_s2743
As Catalyser:
  1. ATR|​pho|​active@Nucleus map + ATRIP@default map → map ATRIP:​ATR|​pho@default map
  2. ATM@default map → map ATM|​S1981_pho|​S367_pho|​S1893_pho|​active@default map
  3. ATR@default map → map ATR|​pho|​active@Nucleus map