Reaction heterodimer_association d_re260 map

ATR|​pho|​active@Nucleus map + ATRIP@default map → ATRIP:​ATR|​pho@default map

Reaction regulators:
Boolean_logic_gate_and
  1. MLH1:​PMS2@default map and MSH2|​pho:​MSH6|​pho@default map
Catalysis
  1. MSH2|​pho:​MSH6|​pho@default map
  2. MLH1:​PMS2@default map
Trigger
  1. gDeaminated_alkylated_mismatched_base*@Nucleus map
  2. gC_NHEJ_DNA_st1*@Nucleus map
  3. gHR_DNA_st1*@Nucleus map
  4. gFanconi_DNA_st1*@Nucleus map
  5. gA_NHEJ_DNA_st1*@Nucleus map


References
DNA with O6-methylguanine adducts, MutSalpha and MutLalpha activate ATR/ATRIP and BER pathways performs the repair:
PMID:16713580, PMID:18543256
Damaged DNA triggers ATR/ATRIP complex activation

Confidence
REF=2 FUNC=5