CDK1:CyclinB1*

Complex CDK1:CyclinB1*

Complex composition:

CDK1|T161_pho:CyclinB1*@default

Identifiers
NAME:CDK1:CyclinB1*

Maps_Modules
dnarepair
dnarepair

References
d_re120( dnarepair ):
By CycB*/CDC2*:
G2/M transition
PMID:16818604
For BRCA2 and FANCD2/FANCDI importance in the cytokinesis and localisation at the spindle and role in the propagation of mitosis:
PMID:15375219, PMID:19686080
CDC2 has to be phosphorylated fot inhibition of G2 to M propagation (called G2 checkpoint). FANCC activates CDC2 phosphorylation
PMID:15377654
Brca1 ubiquitinates CtIp and in complex they inhibit G2 to M propagation (G2 checkpoint)
PMID:16818604, PMID:15485915
BRCA1 and FANCJ in complex inhibit G2 to M propagation (called G2 checkpoint).
PMID:15242590
FANCM:FAAP24 complex activated G2 phase checpoint (G2 to M propagation inhibition):
PMID:18995830
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair:
PMID:16713580, PMID:18543256
BER and MMR interaction and G2/M arrest inresponce to o6-meG formation:
PMID:14614141
d_re313( dnarepair ):
Activation by PLK phosphorylation at S191, S198
Activation by CDC2 phosphorylation at S214
PMID:17596790
d_re383:( dnarepair ) PMID:9892021

Confidence
REF=5 FUNC=5

CDK1|T161_pho|pho:CyclinB1*@default

Identifiers
NAME:CDK1:CyclinB1*

Maps_Modules
dnarepair
dnarepair

Confidence
REF=0 FUNC=5

CDK1|Y14/15_pho|T161_pho:CyclinB1*@default

Identifiers
NAME:CDK1:CyclinB1*

Maps_Modules
dnarepair
dnarepair

References
d_re305:( dnarepair ) CAK phosphorylation of CDC2 is the first step toward complex activation

Confidence
REF=0 FUNC=5

CDK1:CyclinB1*@default

Identifiers
NAME:CDK1:CyclinB1*

Maps_Modules
dnarepair
dnarepair

References
d_re273:( dnarepair ) Wee1 phosphorylation of CDC2 keeps the complex inactive

Confidence
REF=0 FUNC=5

CDK1|Y14/15_pho:CyclinB1*@default

Identifiers
NAME:CDK1:CyclinB1*

Maps_Modules
dnarepair
dnarepair

References
d_re273:( dnarepair ) Wee1 phosphorylation of CDC2 keeps the complex inactive
d_re305:( dnarepair ) CAK phosphorylation of CDC2 is the first step toward complex activation

Confidence
REF=0 FUNC=5

Modifications:
Participates in complexes:
In compartment: default

Participates in reactions:
As Reactant or Product:

As Catalyser: