Protein GADD45A map

Identifiers
Growth arrest and DNA-damage-inducible, alpha
HUGO:GADD45A HGNC:4095 ENTREZ:1647 UNIPROT:P24522 GENECARDS:GADD45A KEGG:1647 ATLASONC:GC_GADD45A WIKI:GADD45A

Maps_Modules
 dnarepair  map
 dnarepair  map
 dnarepair  map

References
PMID:19004803
CyclinB1/CDC2 (CDK1) complex is inhibited by GADD45 in responce to DNA damage and causes G2/M arrest
PMID:12124778, PMID:19652693, PMID:15917306
Role in BER
PMID:23485469

GADD45A@default

References
d_re8( dnarepair  map ):
GADD45 modulated and causes complex formation APE:PCNA. GADD is rgulated by p53:
PMID:17599061, PMID:23485469
d_re254( dnarepair  map ):
GADD45 interacts with PCNA and activates NER-only Global(GG-NER):
PMID:19652693, PMID:10779360

Modifications:
In compartment: default
  1. GADD45A@default map
Participates in complexes:
In compartment: Nucleus
  1. GADD45A:​PCNA@Nucleus map
In compartment: default
  1. CDK1:​CyclinB1*:​GADD45A@default map
Participates in reactions:
As Reactant or Product:
  1. rGADD45*@default map → map GADD45A@default map
  2. GADD45A@default map + PCNA@default map → map GADD45A:​PCNA@Nucleus map
  3. CDK1:​CyclinB1*@default map + GADD45A@default map → map CDK1:​CyclinB1*:​GADD45A@default map
As Catalyser:
  1. gGG-NER_DNA_st2*@Nucleus map → map gTC-NER_GG-NER_DNA_st3*@Nucleus map
  2. G2 phase@default map → map M phase@default map
  3. gGG-NER_DNA_st1*@Nucleus map → map gGG-NER_DNA_st2*@Nucleus map
  4. Mg2+@default map + APE*|​Thr233_pho|​ubi@default map + PCNA@default map + WRN@Nucleus map → map APE*|​Thr233_pho|​ubi:​Mg2+:​PCNA:​WRN@default map