Identifiers
APEX nuclease (multifunctional DNA repair enzyme) 1
HUGO:APEX1 HGNC:587 ENTREZ:328 UNIPROT:P27695 GENECARDS:APEX1 REACTOME:50120 KEGG:328 ATLASONC:GC_APEX1 WIKI:APEX1
APEX nuclease (apurinic/apyrimidinic endonuclease) 2
HUGO:APEX2 HGNC:17889 ENTREZ:27301 UNIPROT:Q9UBZ4 GENECARDS:APEX2 KEGG:27301 ATLASONC:GC_APEX2 WIKI:APEX2

Maps_Modules
 dnarepair 

References
Apyrimidinic endonucleases, APE
PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:20056333, PMID:11585362
For Phosphorylation by CK2
PMID:20955519, PMID:9407949
Inhibitors for APE in combination with oxidative stress to block BER and cause cancer cell death
PMID:23110144, PMID:22455312
CDK5 and MDM2 activate APE for shift to BER activity
PMID:21727086, PMID:21922195

References
d_re554:( dnarepair  ) PMID:21727086, PMID:21922195, PMID:20724832
d_re2:( dnarepair  ) deoxyribose-phosphatase activity of PolB
d_re8( dnarepair  ):
GADD45 modulated and causes complex formation APE:PCNA. GADD is rgulated by p53:
PMID:17599061, PMID:23485469
d_re492( dnarepair  ):
PMID:20955519
PMID:9407949

References
d_re492( dnarepair  ):
PMID:20955519
PMID:9407949

References
d_re554:( dnarepair  ) PMID:21727086, PMID:21922195, PMID:20724832

1. APE*@default
2. APE*|​pho@default
3. APE*|​Thr233_pho|​ubi@default

1. APE*|​Thr233_pho|​ubi:​Mg2+:​PCNA:​WRN@default

1. APE*|​Thr233_pho|​ubi@default → APE*|​pho@default
2. APE*@default → APE*|​Thr233_pho|​ubi@default
3. Mg2+@default + APE*|​Thr233_pho|​ubi@default + PCNA@default + WRN@Nucleus → APE*|​Thr233_pho|​ubi:​Mg2+:​PCNA:​WRN@default

1. gBER_M-glyc_DNA_st2*@Nucleus → gBER_M-glyc_DNA_st3*@Nucleus
2. gBER_M-glyc_DNA_st3*@Nucleus → gShP_BER_M-glyc_st4_B-glyc_DNA_st4*@Nucleus + 5'dRP@default
3. gShP_BER_M-glyc_st4_B-glyc_DNA_st4*@Nucleus + dNTPs@Nucleus → gShP_BER_M-glyc_st5_B-glyc_DNA_st5*@Nucleus
4. gBER_B-glyc_DNA_st3*@Nucleus → gShP_BER_M-glyc_st4_B-glyc_DNA_st4*@Nucleus + 3'ddR5P@default