Identifiers
proliferating cell nuclear antigen
HUGO:PCNA HGNC:8729 ENTREZ:5111 UNIPROT:P12004 GENECARDS:PCNA REACTOME:97870 ATLASONC:PCNAID41670ch20p12 WIKI:PCNA

Maps_Modules
 dnarepair 
 dnarepair 
 dnarepair 
 dnarepair 
 cellcycle 
 survival 

References
PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013

References
d_re247( dnarepair  ):
De-ubiquitination of PCNA serves a negative loop for inactivation of TLS
PMID:16531995
d_re8( dnarepair  ):
GADD45 modulated and causes complex formation APE:PCNA. GADD is rgulated by p53:
PMID:17599061, PMID:23485469
d_re24:( dnarepair  ) PMID:22973052
d_re166( dnarepair  ):
Fanconi recognition complex as FA core complex recruits NER, HR, TLS proteins that collectively repair the ICL. If Fanconi proteins participating in the recognition are dysactivated, there is no any other mechanism to recognize ILSs, therefore, even if NER, HR and TLS are correct, they will not perform the repair without core Fanconi proteins.
PMID:19686080
d_re168( dnarepair  ):
PMID:18157158
Ubiquitination of PCNA by RAD6-RAD18 increases affinity of PCNA to POLH and makes switch from PCNA-POLD to PCNA-POLH and stops translation and initiates TLS pathway
PMID:15280666, PMID:18498753
d_re181( dnarepair  ):
SUMOlated PCNA recognizes stalled replication fork and blocks homologous recombination, re-orients toward TLS
PMID:19217833, PMID:18157158, PMID:19851286
d_re254( dnarepair  ):
GADD45 interacts with PCNA and activates NER-only Global(GG-NER):
PMID:19652693, PMID:10779360

References
d_re181( dnarepair  ):
SUMOlated PCNA recognizes stalled replication fork and blocks homologous recombination, re-orients toward TLS
PMID:19217833, PMID:18157158, PMID:19851286
d_re114( dnarepair  ):
PMID:18171670, PMID:20064462
For regulation of HR by cell cycle. CDK1 is essential to switch cells from C_NHEJ to HR during S/G2 phase: PMID:15496928
The complex BRCA2:FANCC:FANCG:XRCC3 activates HR:
PMID:18212739
For role of BLM:TOP3:RMI1 complex in the HR resection step:
PMID:19490890
For central role of the MRN complex and CtIP in the resection of the DNA that turns on the HR and off C_NHEJ:
PMID:20021983
For inhibition of HR by RECQ5:
PMID:19270065
For role of CDC2 (CDK1) in DNA resection initiation in S/G2 phase, HR initiation:
PMID:15655342, PMID:15549137, PMID:15496928
RNF8:MDC1 complex recruit HR-related proteins by this shifting from C_NHEJ to HR:
PMID:18001825
PMID:19217833
d_re220( dnarepair  ):
Stalled replication fork is mostly induced by ICLs

1. PCNA@default
2. PCNA|​K164_ubi@default
3. PCNA|​K164_don|​K127_don@default
4. PCNA|​K164_ubi|​ubi|​ubi|​ubi@default

1. GADD45A:​PCNA@Nucleus
2. EXO1:​PCNA:​RFC*:​RPA1:​RPA2:​RPA3:​hMutL*:​hMutS*@Nucleus

1. CTIP*|​emp:​PCNA@default
2. PCNA|​K164_ubi:​REV1@default
3. PCNA|​K164_ubi:​POLZ*@default
4. FEN1:​PCNA:​WRN@default
5. PCNA|​K164_ubi:​POLH:​REV1@default
6. PCNA|​K164_ubi:​POLI:​REV1@default
7. PCNA|​K164_ubi:​POLK:​REV1@default
8. LIG1:​PARP1|​PolyADPribose_unk|​pho:​PCNA@default
9. APE*|​Thr233_pho|​ubi:​Mg2+:​PCNA:​WRN@default
10. PARP1:​PCNA:​POLB:​POLD*:​POLE*:​RFC*@default
11. ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​PCNA|​K164_ubi:​TIM1*@default
12. BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​H2AFX|​S139_pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default
13. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​S139_pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default
14. CHTF18:​PCNA:​POLD*:​POLE*:​POLK:​RFC*:​RPA1:​RPA2|​pho:​RPA3:​XRCC1|​pho@default

1. POLB@default + PCNA@default + POLE*@default + POLD*@default + PARP1|​PolyADPribose_unk|​pho@Nucleus + RFC*@Nucleus → PARP1:​PCNA:​POLB:​POLD*:​POLE*:​RFC*@default
2. d_s2743 + d_s834 + EXO1@default + RPA1:​RPA2:​RPA3@default + PCNA@default + RFC*@Nucleus → EXO1:​PCNA:​RFC*:​RPA1:​RPA2:​RPA3:​hMutL*:​hMutS*@Nucleus
3. FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho@default + BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@default + BRCA2@default + NBS1*|​S343_pho@default + RAD51@default + PCNA@default + H2AFX|​S139_pho|​ubi@default + TIP60*@default → BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​S139_pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default
4. PCNA@default → PCNA|​K164_ubi@default
5. PCNA|​K164_ubi@default + POLK@default + REV1@default → PCNA|​K164_ubi:​POLK:​REV1@default
6. PCNA|​K164_ubi@default + POLI@default + REV1@default → PCNA|​K164_ubi:​POLI:​REV1@default
7. PCNA|​K164_ubi@default + REV1@default → PCNA|​K164_ubi:​REV1@default
8. PCNA|​K164_ubi@default + POLZ*@default → PCNA|​K164_ubi:​POLZ*@default
9. PCNA@default → PCNA|​K164_don|​K127_don@default
10. PCNA|​K164_ubi@default → PCNA|​K164_ubi|​ubi|​ubi|​ubi@default
11. CTIP*|​emp@default + PCNA@default → CTIP*|​emp:​PCNA@default
12. POLE*@default + POLD*@default + RFC*@Nucleus + PCNA@default + CHTF18@default + POLK@default + XRCC1|​pho@default + RPA1:​RPA2|​pho:​RPA3@default → CHTF18:​PCNA:​POLD*:​POLE*:​POLK:​RFC*:​RPA1:​RPA2|​pho:​RPA3:​XRCC1|​pho@default
13. PCNA@default + FEN1@default + WRN@Nucleus → FEN1:​PCNA:​WRN@default
14. PCNA|​K164_ubi@default → PCNA@default
15. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​S139_pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default → BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​H2AFX|​S139_pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default
16. PCNA@default + LIG1@default + PARP1|​PolyADPribose_unk|​pho@Nucleus → LIG1:​PARP1|​PolyADPribose_unk|​pho:​PCNA@default
17. GADD45A@default + PCNA@default → GADD45A:​PCNA@Nucleus
18. TIM1*@default + CLSPN|​pho@default + PCNA|​K164_ubi@default + ATRIP:​ATR|​pho@default + CHEK1|​pho|​active@Nucleus → ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​PCNA|​K164_ubi:​TIM1*@default
19. REV1@default + PCNA|​K164_ubi@default + POLH@default → PCNA|​K164_ubi:​POLH:​REV1@default
20. Mg2+@default + APE*|​Thr233_pho|​ubi@default + PCNA@default + WRN@Nucleus → APE*|​Thr233_pho|​ubi:​Mg2+:​PCNA:​WRN@default

1. gBER_M-glyc_DNA_st2*@Nucleus → gBER_M-glyc_DNA_st3*@Nucleus
2. gHR_DNA_st1*@Nucleus → gHR_DNA_st2*@Nucleus
3. S phase@default → G2 phase@default
4. gGG-NER_DNA_st2*@Nucleus → gTC-NER_GG-NER_DNA_st3*@Nucleus
5. gHR_DNA_st2*@Nucleus → gHR_DNA_st3*@Nucleus
6. gHR_DNA_st6*@Nucleus → gHR_DNA_st7*@Nucleus
7. gFanconi_DNA_st4*@Nucleus → gHR_DNA_st2*@Nucleus
8. gDamaged_DNA*@Nucleus → gRepaired_DNA*@Nucleus
9. gLnP_BER_M-glyc_st5*@Nucleus → gLnP_BER_M-glyc_st6*@Nucleus
10. gHR_DNA_st1*@Nucleus → gFanconi_DNA_st1*@Nucleus
11. gGG-NER_DNA_st1*@Nucleus → gGG-NER_DNA_st2*@Nucleus
12. gTC-NER_GG-NER_DNA_st4*@Nucleus + dNTPs@Nucleus → gTC-NER_GG-NER_DNA_st5*@Nucleus
13. gMMR_DNA_st2*@Nucleus → gMMR_DNA_st3*@Nucleus
14. gBER_M-glyc_DNA_st3*@Nucleus + dNTPs@default → gLnP_BER_M-glyc_st4*@Nucleus
15. No DNA replicarion@default → DNA replicarion@default
16. gTLS_DNA_st1*@Nucleus → gTLS_DNA_st2*@Nucleus
17. gBER_B-glyc_DNA_st3*@Nucleus → gShP_BER_M-glyc_st4_B-glyc_DNA_st4*@Nucleus + 3'ddR5P@default
18. gLnP_BER_M-glyc_st4*@Nucleus → gLnP_BER_M-glyc_st5*@Nucleus + Modified 2-12 nucl fragment@default