FANCD2

Protein FANCD2

Identifiers
Fanconi anemia, complementation group D2
HUGO:FANCD2 HGNC:3585 ENTREZ:2177 UNIPROT:Q9BXW9 GENECARDS:FANCD2 REACTOME:229217 KEGG:2177 ATLASONC:FAD WIKI:FANCD2

Maps_Modules
dnarepair
dnarepair

References
PMID:19686080, PMID:19622404, PMID:18931676, PMID:22751496, PMID:23444773, PMID:20723763

FANCD2|S222_pho@default

References
d_re198( dnarepair ):
ATM phosphotylates FANCD2 for S-phase checkpoint arrest in responce to IR.
PMID:12086603
d_re115( dnarepair ):
PMID:16581787,
For inhibition of S-checkpoint by ATM:
PMID:15175241
Inhibition of Sphase by MRE complex:
PMID:17713585
By CycE*/CDK2: G1/S transition
By CycD*/CDK2/CIp/KIP: checkpoint G1/S
d_re119( dnarepair ):
PMID:15175241, PMID:12086603
For inhibition of S-checkpoint by HCLK2/FAAP24/ATR/FANKM complex:
PMID:19282663, PMID:19622404, PMID:18995830
For interaction between SNM1B and ATM to mediate S-phase checkpoint in response to ICL (intra-chromatide lesion):
PMID:18469862
Resected DNA is a triger for activating the S-phase checkpoint and moving from G1 to S to G2:
PMID:20051983, PMID:16805667
For inhibition of S to G2 propagation and activation of S-phase checkpoint by complex PCNA:CtIP:
PMID:19342888
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair. ATR/ATRIP S phase arrest is activated:
PMID:16713580
For role of TIM1*/TIPIN in S-phase checkpoint, stalled replication forks stabilisation and DNA repair during S-phase:
PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221
For inhibition of S-phase by ATR/ATRIP/CHEK1/CLSPN/HCLK2* complex:
PMID:19793801, PMID:17384638
For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint
PMID:15798197
Formation of the complex for crosslink-activation of S phase checkpoint. FA core complex activates the reaction to stop S-phase propagaton:
PMID:14988723, PMID:15136767

FANCD2|K561_ubi|pho@default

References
d_re158( dnarepair ):
S phase checkpoint controls and induces FANCD2 monoubiquitusation to start Fanconi and HR
PMID:12239151
d_re146( dnarepair ):
Link between Fanconi and HR:
PMID:15650050, PMID:19686080
d_re162( dnarepair ):
Link between HR, NER to Fanconi anemia pathway.
PMID:19686080
For ERCC1/XPF:
PMID:10882712, PMID:19805513
For MUS81/Eme1:
PMID:17036055:G
FANCA modulates XPF function:
MRN complex, FANCD2 and SNM1B are modulators of the DNA to release stalled fork:
PMD:19622404
d_re206( dnarepair ):
Phosphorylation of NBS1 bt ATR in responce to crosslink-activation of S phase checkpoint
PMID:15136767
Formation of the complex for crosslink-activation of S phase checkpoint. FA core complex activates the reaction to stop cell cycle propagation:
PMID:14988723

FANCD2|pho@default

References
d_re187( dnarepair ):
PMID:18931676, PMID:19686080
Link between cell cycle and activation of Fanconi pathway
NBS1 is required for FANCD2 phosphorylation and relocation into the FA core complex:
PMID:14988723
d_re158( dnarepair ):
S phase checkpoint controls and induces FANCD2 monoubiquitusation to start Fanconi and HR
PMID:12239151

FANCD2@default

References
d_re187( dnarepair ):
PMID:18931676, PMID:19686080
Link between cell cycle and activation of Fanconi pathway
NBS1 is required for FANCD2 phosphorylation and relocation into the FA core complex:
PMID:14988723
d_re198( dnarepair ):
ATM phosphotylates FANCD2 for S-phase checkpoint arrest in responce to IR.
PMID:12086603

Modifications:
In compartment: default

FANCD2@default
FANCD2|pho@default
FANCD2|S222_pho@default
FANCD2|K561_ubi|pho@default

Participates in complexes:
In compartment: default

Participates in reactions:
As Reactant or Product:

As Catalyser: