Gene HR_DNA_st1* map

Identifiers
HR:DNA:st1
DNA with double strand break or interstrand crosslink (ICL)
Node_Type:Generic

Maps_Modules
 dnarepair  map

References
PMID:22258607, PMID:22918414, PMID:20723763
PMID:22920291, PMID:23897299, PMID:23892398,
HR in dividing and non-dividing cells
PMID:23684800
Double strand break trigers MRN complex association:first step in DNA damage recognition and initiation of G2/M checkpoint
PMID:17303408
Interstrand crosslinking agents activate HR
PMID:21701511
Ends resection
PMID:21910633
HR as part of stalled replication fork resolution
PMID:23637285

gHR_DNA_st1*@Nucleus

References
d_re515( dnarepair  map ):
http://dnatraffic.ibb.waw.pl/classification/dna_damages
PMID:22258607, PMID:19267553, PMID:18256616
FOR HR activation by IR
PMID:20723763
For HR activation by UV
PMID:21885354, PMID:22987150, PMID:20206282, PMID:19398948, PMID:1575062
Interstrand crosslinking agents activate HR
PMID:21701511
Topoisomerate inhibitors bloch double strand DNA repair by HR, C_NHEJ and Fanconi pathways
PMID:23259582
For HR
PMID:22123462, PMID:20693240
FOR Fanconi
PMID:21414716, PMID:23157317
For activation by Dbait
PMID:22068457, PMID:22815765, PMID:22042585, PMID:19621083
d_re594:( dnarepair  map ) reactionType:is.a
d_re36( dnarepair  map ):
PMID:16332722
Auto-phosphorylation of ATM in response to DNA DSB:
PMID:17303408, PMID:12556884, PMID:16858402
Amplification of ATM auto-phosphorylation by the complex ATM:MRNcomplex:H2AX:MDC1CDK5 phosphorylates and activates ATM
PMID:19151707
d_re91( dnarepair  map ):
MRN complex:
PMID:16531125, PMID:17303408
Double strand breaks sensor.
MRN complex association is a first event after the DNA damage.
d_re113:( dnarepair  map ) PMID:18171670
d_re114( dnarepair  map ):
PMID:18171670, PMID:20064462
For regulation of HR by cell cycle. CDK1 is essential to switch cells from C_NHEJ to HR during S/G2 phase: PMID:15496928
The complex BRCA2:FANCC:FANCG:XRCC3 activates HR:
PMID:18212739
For role of BLM:TOP3:RMI1 complex in the HR resection step:
PMID:19490890
For central role of the MRN complex and CtIP in the resection of the DNA that turns on the HR and off C_NHEJ:
PMID:20021983
For inhibition of HR by RECQ5:
PMID:19270065
For role of CDC2 (CDK1) in DNA resection initiation in S/G2 phase, HR initiation:
PMID:15655342, PMID:15549137, PMID:15496928
RNF8:MDC1 complex recruit HR-related proteins by this shifting from C_NHEJ to HR:
PMID:18001825
SUMOlated PCNA recognizes stalled replication fork and blocks homologous recombination, re-orients toward TLS
PMID:19217833
d_re199( dnarepair  map ):
HCLK2*/FANCM/FAAP24/active ATR complex inhibit S-phase:
PMID:19282663, PMID:19622404, PMID:18995830
d_re215( dnarepair  map ):
If the cell is in G1 phase, the double strand break will be repeated by C_NHEJ, because there is no homologous template from sister chromatide. If the cell is in S/G2 phase, HR will take place.
d_re220( dnarepair  map ):
Stalled replication fork is mostly induced by ICLs
d_re260( dnarepair  map ):
DNA with O6-methylguanine adducts, MutSalpha and MutLalpha activate ATR/ATRIP and BER pathways performs the repair:
PMID:16713580, PMID:18543256
Damaged DNA triggers ATR/ATRIP complex activation

Modifications:
In compartment: Nucleus
  1. gHR_DNA_st1*@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gHR_DNA_st1*@Nucleus map → map gHR_DNA_st2*@Nucleus map
    2. gHR_DNA_st1*@Nucleus map → map gC_NHEJ_DNA_st1*@Nucleus map
    3. gHR_DNA_st1*@Nucleus map → map gDamaged_DNA*@Nucleus map
    4. gHR_DNA_st1*@Nucleus map → map gFanconi_DNA_st1*@Nucleus map
    5. gDeaminated_alkylated_mismatched_base*@Nucleus map → map gHR_DNA_st1*@Nucleus map
    6. gOxidized_ring-saturated_hydrolysed_base*@Nucleus map → map gHR_DNA_st1*@Nucleus map
    7. gIntact_DNA*@Nucleus map → map gHR_DNA_st1*@Nucleus map
    8. gDouble_strand_breaks_DSB*@Nucleus map → map gHR_DNA_st1*@Nucleus map
    9. gInterstrand_crosslinks_ICL*@Nucleus map → map gHR_DNA_st1*@Nucleus map
    As Catalyser:
    1. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi@default map + MRE11*:​NBS1*|​S343_pho:​RAD50@default map + PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho@default map → map BRCA1:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi:​MRE11*:​NBS1*|​S343_pho:​PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho:​RAD50@default map
    2. HCLK2*@default map + FAAP24*@default map + FANCM@default map + ATR|​pho|​active@Nucleus map → map ATR|​pho:​FAAP24*:​FANCM:​HCLK2*@default map
    3. ATR|​pho|​active@Nucleus map + ATRIP@default map → map ATRIP:​ATR|​pho@default map
    4. ATM@default map → map ATM|​S1981_pho|​S367_pho|​S1893_pho|​active@default map
    5. PPP5C:​RAD17@default map → map PPP5C@default map + RAD17@default map
    6. PARP2|​unk|​pho@default map + PARP1|​PolyADPribose_unk|​pho@Nucleus map → map PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho@default map
    7. MRE11*@default map + RAD50@default map + NBS1*|​S343_pho@default map → map MRE11*:​NBS1*|​S343_pho:​RAD50@default map