Gene Fanconi_DNA_st1* map

Identifiers
Fanconi:DNA:st1
DNA with inter chromasomal crosslinks (ICL) and/or stalled replication fork and/or intrachromasomal crosslinks
induced by X rays or UV light or alkylators (cisplatin, mitomycin C, nitrogen mustard)
Node_Type:Generic

Maps_Modules
 dnarepair  map

References
PMID:22258607, PMID:22918414
PMID:23444773, PMID:23637285, PMID:23892398
For activation of Fanconi by UV light
PMID:17145857, PMUID:22751496
Fanconi is activated by interstrand crosslinking agents
PMID:23444773, PMID:21948210, PMID:21701511

gFanconi_DNA_st1*@Nucleus

References
d_re220( dnarepair  map ):
SUMOlated PCNA recognizes stalled replication fork and blocks homologous recombination, re-orients toward TLS
PMID:19217833
Stalled replication fork is mostly induced by ICLs
d_re520( dnarepair  map ):
http://dnatraffic.ibb.waw.pl/classification/dna_damages
For Fanconi
PMID:17145857
Fanconi is activated by interstrand crosslinking agents
PMID:23444773, PMID:21948210, PMID:21701511
Topoisomerate inhibitors bloch double strand DNA repair by HR, C_NHEJ and Fanconi pathways
PMID:23259582
For HR
PMID:22123462, PMID:20693240
PMID:21414716, PMID:23157317
d_re586:( dnarepair  map ) reactionType:is.a
d_re36( dnarepair  map ):
PMID:16332722
Auto-phosphorylation of ATM in response to DNA DSB:
PMID:17303408, PMID:12556884, PMID:16858402
Amplification of ATM auto-phosphorylation by the complex ATM:MRNcomplex:H2AX:MDC1CDK5 phosphorylates and activates ATM
PMID:19151707
d_re37( dnarepair  map ):
PMID:16332722, PMID:15136767
ATR binds stalled fork and phosphorylates CHK1 that activates checkpoint, stops cell cycle
d_re91( dnarepair  map ):
MRN complex:
PMID:16531125, PMID:17303408
Double strand breaks sensor.
MRN complex association is a first event after the DNA damage.
d_re185( dnarepair  map ):
For hyper-phosphotyration of REV1 in cell cycle and DNA damage-dependent manner. Hyper-phosphorylation makes REV1 regulatory molecule for activating TLS pathway
PMID:17035102, PMID:19258535
d_re187( dnarepair  map ):
PMID:18931676, PMID:19686080
Link between cell cycle and activation of Fanconi pathway
NBS1 is required for FANCD2 phosphorylation and relocation into the FA core complex:
PMID:14988723
d_re199( dnarepair  map ):
HCLK2*/FANCM/FAAP24/active ATR complex inhibit S-phase:
PMID:19282663, PMID:19622404, PMID:18995830
d_re209( dnarepair  map ):
For interaction between SNM1B and ATM to mediate S-phase checkpoint in response to ICL (intra-chromatide lesion):
PMID:18469862
d_re260( dnarepair  map ):
DNA with O6-methylguanine adducts, MutSalpha and MutLalpha activate ATR/ATRIP and BER pathways performs the repair:
PMID:16713580, PMID:18543256
Damaged DNA triggers ATR/ATRIP complex activation

Modifications:
In compartment: Nucleus
  1. gFanconi_DNA_st1*@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gFanconi_DNA_st1*@Nucleus map → map gFanconi_DNA_st2*@Nucleus map
    2. gHR_DNA_st1*@Nucleus map → map gFanconi_DNA_st1*@Nucleus map
    3. gIntact_DNA*@Nucleus map → map gFanconi_DNA_st1*@Nucleus map
    4. gInterstrand_crosslinks_ICL*@Nucleus map → map gFanconi_DNA_st1*@Nucleus map
    5. gStalled_replication_fork*@Nucleus map → map gFanconi_DNA_st1*@Nucleus map
    6. gIntrastrand_crosslinks*@Nucleus map → map gFanconi_DNA_st1*@Nucleus map
    As Catalyser:
    1. FAAP24*@default map + FANCM@default map → map FAAP24*:​FANCM@default map
    2. REV1|​pho@default map → map REV1|​pho|​pho|​pho@default map
    3. FANCD2@default map → map FANCD2|​pho@default map
    4. HCLK2*@default map + FAAP24*@default map + FANCM@default map + ATR|​pho|​active@Nucleus map → map ATR|​pho:​FAAP24*:​FANCM:​HCLK2*@default map
    5. ATM|​S1981_pho|​S367_pho|​S1893_pho|​active@default map + SNM1B*@default map → map ATM|​S1981_pho|​S367_pho|​S1893_pho:​SNM1B*@default map
    6. ATR|​pho|​active@Nucleus map + ATRIP@default map → map ATRIP:​ATR|​pho@default map
    7. ATM@default map → map ATM|​S1981_pho|​S367_pho|​S1893_pho|​active@default map
    8. ATR@default map → map ATR|​pho|​active@Nucleus map
    9. PPP5C:​RAD17@default map → map PPP5C@default map + RAD17@default map
    10. MRE11*@default map + RAD50@default map + NBS1*|​S343_pho@default map → map MRE11*:​NBS1*|​S343_pho:​RAD50@default map