Protein TAK1
TAK1@Cell membrane
Originally identified as a MKKK that acts upstream of members of the stress-activated MAP kinase family

---

Modifications:
In compartment: Cell membrane

1. TAK1@Cell membrane

Participates in complexes:
In compartment: Cell membrane

1. MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane
2. IKK_alpha:​IKK_beta:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane
3. IKK_alpha|​pho:​IKK_beta|​pho:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane

Participates in reactions:
As Reactant or Product:

1. TAK1@Cell membrane → TAK1@Cell membrane
2. TAK1@Cell membrane → TAK1@Cell membrane
3. TAK1@Cell membrane + RIP1|​K377_ubi:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane → MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane
4. MEKK3@Cell membrane + RIP1|​K377_ubi:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane → MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane
5. IKK_alpha:​IKK_beta:​IKK_gamma_/NEMO@Cell membrane + MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane → IKK_alpha:​IKK_beta:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane
6. IKK_alpha:​IKK_beta:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane → IKK_alpha|​pho:​IKK_beta|​pho:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane
7. IKK_alpha:​IKK_beta:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane → IKK_alpha|​pho:​IKK_beta|​pho:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane
8. IKK_alpha|​pho:​IKK_beta|​pho:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane → IKK_beta|​pho|​active@Cell membrane
9. IKK_alpha|​pho:​IKK_beta|​pho:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane → IKK_alpha|​pho|​active@Cell membrane

As Catalyser:

1. AMP:​AMPK_alpha:​AMPK_beta:​AMPK_gamma@Cell membrane → AMP:​AMPK_alpha|​T172_pho:​AMPK_beta:​AMPK_gamma@Cell membrane
2. IKK_alpha:​IKK_beta:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane → IKK_alpha|​pho:​IKK_beta|​pho:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane
3. IKK_alpha:​IKK_beta:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane → IKK_alpha|​pho:​IKK_beta|​pho:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane
4. I_kappa_B_alpha_:​p50 (NF_kappa_B):​p65(NF_kappa_B)@Cell membrane → I_kappa_B_alpha_|​S32_pho|​S36_pho:​p50 (NF_kappa_B):​p65(NF_kappa_B)@Cell membrane