Protein IKK_beta

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Modifications:
In compartment: Cell membrane

1. IKK_beta@Cell membrane
2. IKK_beta|​pho|​active@Cell membrane

Participates in complexes:
In compartment: Cell membrane

1. FoxO1/3a:​IKK_beta|​pho@Cell membrane
2. FoxO1/3a|​S644_pho:​IKK_beta|​pho@Cell membrane
3. FoxO1/3a|​S644_pho|​ubi:​IKK_beta|​pho@Cell membrane
4. IKK_alpha:​IKK_beta:​IKK_gamma_/NEMO@Cell membrane
5. IKK_alpha:​IKK_beta:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane
6. IKK_alpha|​pho:​IKK_beta|​pho:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane

In compartment: Endomembrane

1. IKK_beta|​pho:​TSC1|​S487_pho|​S511_pho@Endomembrane
2. IKK_beta|​pho:​TSC1:​TSC2@Endomembrane
3. IKK_beta|​pho:​TSC1|​S487_pho|​S511_pho:​TSC2@Endomembrane

Participates in reactions:
As Reactant or Product:

1. IKK_alpha@Cell membrane + IKK_beta@Cell membrane → IKK_alpha:​IKK_beta:​IKK_gamma_/NEMO@Cell membrane
2. IKK_gamma_/NEMO@Cell membrane + IKK_beta@Cell membrane → IKK_alpha:​IKK_beta:​IKK_gamma_/NEMO@Cell membrane
3. IKK_alpha:​IKK_beta:​IKK_gamma_/NEMO@Cell membrane + MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane → IKK_alpha:​IKK_beta:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane
4. IKK_alpha:​IKK_beta:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane → IKK_alpha|​pho:​IKK_beta|​pho:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane
5. IKK_alpha:​IKK_beta:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane → IKK_alpha|​pho:​IKK_beta|​pho:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane
6. IKK_beta|​pho:​TSC1:​TSC2@Endomembrane → IKK_beta|​pho:​TSC1|​S487_pho|​S511_pho:​TSC2@Endomembrane
7. IKK_beta|​pho:​TSC1|​S487_pho|​S511_pho:​TSC2@Endomembrane → IKK_beta|​pho:​TSC1|​S487_pho|​S511_pho@Endomembrane + TSC2@Cell membrane
8. IKK_alpha|​pho:​IKK_beta|​pho:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane → IKK_beta|​pho|​active@Cell membrane
9. IKK_beta|​pho|​active@Cell membrane + TSC1:​TSC2@Endomembrane → IKK_beta|​pho:​TSC1:​TSC2@Endomembrane
10. IKK_alpha|​pho:​IKK_beta|​pho:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane → IKK_alpha|​pho|​active@Cell membrane
11. IKK_beta|​pho|​active@Cell membrane + FoxO1/3a@Cell membrane → FoxO1/3a:​IKK_beta|​pho@Cell membrane
12. FoxO1/3a:​IKK_beta|​pho@Cell membrane → FoxO1/3a|​S644_pho:​IKK_beta|​pho@Cell membrane
13. FoxO1/3a|​S644_pho|​ubi:​IKK_beta|​pho@Cell membrane → degraded
14. FoxO1/3a|​S644_pho:​IKK_beta|​pho@Cell membrane → FoxO1/3a|​S644_pho|​ubi:​IKK_beta|​pho@Cell membrane

As Catalyser:

1. IKK_alpha:​IKK_beta:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane → IKK_alpha|​pho:​IKK_beta|​pho:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane
2. IKK_alpha:​IKK_beta:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane → IKK_alpha|​pho:​IKK_beta|​pho:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane
3. I_kappa_B_alpha_:​p50 (NF_kappa_B):​p65(NF_kappa_B)@Cell membrane → I_kappa_B_alpha_|​S32_pho|​S36_pho:​p50 (NF_kappa_B):​p65(NF_kappa_B)@Cell membrane
4. IKK_beta|​pho:​TSC1:​TSC2@Endomembrane → IKK_beta|​pho:​TSC1|​S487_pho|​S511_pho:​TSC2@Endomembrane
5. FoxO1/3a:​IKK_beta|​pho@Cell membrane → FoxO1/3a|​S644_pho:​IKK_beta|​pho@Cell membrane