Protein PP2A

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Modifications:
In compartment: Cell membrane

1. PP2A@Cell membrane
2. PP2A|​pho@Cell membrane

In compartment: Nucleus

1. PP2A@Nucleus

Participates in complexes:
In compartment: Cell membrane

1. PP2A:​Paxillin@Cell membrane
2. PP2A:​Paxillin|​Y118_pho|​Y31_pho|​Y40_pho|​S273_pho@Cell membrane
3. ?:​PP2A:​SF2/ASF@Cell membrane
4. 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA@Cell membrane
5. ?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
6. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA@Cell membrane
7. 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
8. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane

In compartment: Nucleus

1. PP2A:​alpha-4@Nucleus
2. (PP2A:​alpha-4|​pho)|​active@Nucleus

Participates in reactions:
As Reactant or Product:

1. PP2A@Cell membrane → PP2A|​pho@Cell membrane
2. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA@Cell membrane → 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA@Cell membrane
3. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → ?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane + 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho@Cell membrane
4. SF2/ASF@Cell membrane + ?@Cell membrane → ?:​PP2A:​SF2/ASF@Cell membrane
5. PP2A@Cell membrane + ?@Cell membrane → ?:​PP2A:​SF2/ASF@Cell membrane
6. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​eIF4E:​m7GTP:​mRNA@Cell membrane + ?:​PP2A:​SF2/ASF@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA@Cell membrane
7. mTOR@Cell membrane + 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA@Cell membrane → 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
8. 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
9. 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
10. ?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → mRNA translation@Cell membrane
11. PP2A@Cell membrane → PP2A@Nucleus
12. Paxillin|​Y118_pho|​Y31_pho|​Y40_pho|​S273_pho@Cell membrane + PP2A@Cell membrane → PP2A:​Paxillin|​Y118_pho|​Y31_pho|​Y40_pho|​S273_pho@Cell membrane
13. PP2A:​Paxillin|​Y118_pho|​Y31_pho|​Y40_pho|​S273_pho@Cell membrane → PP2A:​Paxillin@Cell membrane
14. PP2A:​alpha-4@Nucleus → (PP2A:​alpha-4|​pho)|​active@Nucleus

As Catalyser:

1. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​eIF4E:​m7GTP:​mRNA@Cell membrane → 4EBP-1:​eIF4E:​m7GTP:​mRNA@Cell membrane
2. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA@Cell membrane → 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA@Cell membrane
3. 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
4. 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
5. APC:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin@Cell membrane → APC:​Axin:​CK1:​GSK3alpha/beta:​_beta_Catenin@Cell membrane
6. Pol I:​TIF-1A|​S44_pho|​S170_pho|​S172_pho:​TIF-1B/SL1:​UBF|​pho|​ace|​S484_pho|​S388_pho|​hm2:​rDNA@Nucleus → Pol I:​TIF-1A|​S170_pho|​S172_pho:​TIF-1B/SL1:​UBF|​pho|​ace|​S484_pho|​S388_pho|​hm2:​rDNA@Nucleus
7. PP2A:​Paxillin|​Y118_pho|​Y31_pho|​Y40_pho|​S273_pho@Cell membrane → PP2A:​Paxillin@Cell membrane
8. Rac@Cell membrane → Rac@Cell membrane
9. AKT|​T308_pho|​S473_pho|​T450_pho:​PI3,4,5-P_sub_3@Cell membrane → AKT:​PI3,4,5-P_sub_3@Cell membrane
10. FoxO1/3a|​S253_pho|​T24/32_pho|​S315_pho@Nucleus → FoxO1/3a@Nucleus
11. p53|​S15_pho@Nucleus → p53@Nucleus