Protein 4EBP-1

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Modifications:
In compartment: Cell membrane

1. 4EBP-1@Cell membrane
2. 4EBP-1|​T37_pho|​T46_pho@Cell membrane
3. 4EBP-1|​T37_pho|​T46_pho|​S70_pho@Cell membrane
4. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho@Cell membrane
5. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho|​S83_pho|​S101_pho|​S112_pho@Cell membrane

Participates in complexes:
In compartment: Cell membrane

1. 4EBP-1:​eIF4E:​m7GTP:​mRNA@Cell membrane
2. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​eIF4E:​m7GTP:​mRNA@Cell membrane
3. 4EBP-1:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
4. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
5. 4EBP-1:​S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​m7GTP:​mRNA@Cell membrane
6. 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA@Cell membrane
7. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA@Cell membrane
8. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​Raptor|​S722_pho|​S719_pho|​S721_pho:​S6K1|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
9. 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
10. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
11. 4EBP-1:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane

Participates in reactions:
As Reactant or Product:

1. 4EBP-1@Cell membrane → 4EBP-1|​T37_pho|​T46_pho@Cell membrane
2. 4EBP-1@Cell membrane → 4EBP-1|​T37_pho|​T46_pho@Cell membrane
3. 4EBP-1|​T37_pho|​T46_pho@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S70_pho@Cell membrane
4. 4EBP-1|​T37_pho|​T46_pho|​S70_pho@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho@Cell membrane
5. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho|​S83_pho|​S101_pho|​S112_pho@Cell membrane
6. 4EBP-1@Cell membrane + eIF4E:​m7GTP:​mRNA@Cell membrane → 4EBP-1:​eIF4E:​m7GTP:​mRNA@Cell membrane
7. S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3@Cell membrane + 4EBP-1:​eIF4E:​m7GTP:​mRNA@Cell membrane → 4EBP-1:​S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​m7GTP:​mRNA@Cell membrane
8. FKBP38:​GTP:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​Rheb:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane + 4EBP-1:​S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​m7GTP:​mRNA@Cell membrane → 4EBP-1:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
9. 4EBP-1:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​Raptor|​S722_pho|​S719_pho|​S721_pho:​S6K1|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
10. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​Raptor|​S722_pho|​S719_pho|​S721_pho:​S6K1|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → Raptor|​S722_pho|​S719_pho|​S721_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane + 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho@Cell membrane
11. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​Raptor|​S722_pho|​S719_pho|​S721_pho:​S6K1|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → Raptor|​S722_pho|​S719_pho|​S721_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane + S6K1|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho|​active@Cell membrane
12. 4EBP-1:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​Raptor|​S722_pho|​S719_pho|​S721_pho:​S6K1|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
13. 4EBP-1:​eIF4E:​m7GTP:​mRNA@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​eIF4E:​m7GTP:​mRNA@Cell membrane
14. 4EBP-1:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
15. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​eIF4E:​m7GTP:​mRNA@Cell membrane → eIF4E:​m7GTP:​mRNA@Cell membrane + 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho@Cell membrane
16. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane + 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho@Cell membrane
17. SF2/ASF:​mTOR@Cell membrane + 4EBP-1:​eIF4E:​m7GTP:​mRNA@Cell membrane → 4EBP-1:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
18. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​eIF4E:​m7GTP:​mRNA@Cell membrane → 4EBP-1:​eIF4E:​m7GTP:​mRNA@Cell membrane
19. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA@Cell membrane → 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA@Cell membrane
20. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → ?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane + 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho@Cell membrane
21. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​eIF4E:​m7GTP:​mRNA@Cell membrane + ?:​PP2A:​SF2/ASF@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA@Cell membrane
22. mTOR@Cell membrane + 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA@Cell membrane → 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
23. 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
24. 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane

As Catalyser:

1. eIF4E:​m7GTP:​mRNA@Cell membrane + eIF4G|​S1108_pho|​S1148_pho|​S1192_pho@Cell membrane → eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
2. 4EBP-1:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​Raptor|​S722_pho|​S719_pho|​S721_pho:​S6K1|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
3. 4EBP-1:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​Raptor|​S722_pho|​S719_pho|​S721_pho:​S6K1|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
4. 4EBP-1:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
5. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA@Cell membrane → 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA@Cell membrane
6. 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
7. 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane