Protein mTOR
PMID:12150926
PMID:12150925
PMID:12408816
Four phosphorylation sites (P-sites) on mTOR have been reported to date (T2446, S2448, S2481 and S1261). However, only S1261 has been described to regulates mTORC1 function (PMID:19487463). In addition, mTOR autokinase activity (S2481 autophosphorylation) requires S1261 phosphorylation. Therefore, we decided to illustrate mTOR with both the S1261 and S2481 P-sites on this map.
mTOR@Cell membrane
PMID:12150926
PMID:12150925
PMID:12408816
mTOR@ER-Golgi Network
PMID:12150926
PMID:12150925
PMID:12408816

---

Modifications:
In compartment: Cell membrane

1. mTOR@Cell membrane
2. mTOR|​S1261_pho@Cell membrane
3. mTOR|​T2446_pho@Cell membrane
4. mTOR|​S2448_pho|​T2446_pho@Cell membrane
5. mTOR|​S2481_pho|​S1261_pho|​ubi@Cell membrane
6. mTOR|​S2481_pho|​S1261_pho|​active@Cell membrane

In compartment: ER-Golgi Network

1. mTOR@ER-Golgi Network
2. mTOR|​S2481_pho|​S1261_pho|​active@ER-Golgi Network

In compartment: Nucleus

1. mTOR|​S2481_pho|​S1261_pho|​active@Nucleus

Participates in complexes:
In compartment: Cell membrane

1. PML:​mTOR@Cell membrane
2. PP30:​mTOR@Cell membrane
3. PP242:​mTOR@Cell membrane
4. Torin:​mTOR@Cell membrane
5. XL765:​mTOR@Cell membrane
6. PI-103:​mTOR@Cell membrane
7. SF2/ASF:​mTOR@Cell membrane
8. Ku-0063794:​mTOR@Cell membrane
9. NVP-BEZ235:​mTOR@Cell membrane
10. Tel2:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
11. CLIP-170:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
12. CLIP-170|​pho:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
13. Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
14. Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
15. Rictor:​Sin1.1:​mLST8:​mTOR@Cell membrane
16. Rictor:​Sin1.2:​mLST8:​mTOR@Cell membrane
17. Rictor:​Sin1.5:​mLST8:​mTOR@Cell membrane
18. PA:​Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
19. DEPTOR:​Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
20. FKBP38:​Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
21. Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
22. Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
23. Rictor:​Sin1.2:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
24. Rictor:​Sin1.5:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
25. DEPTOR|​pho:​Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
26. Rictor|​T1135_pho:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
27. SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
28. PA:​Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
29. JNK:​Rictor:​Sin1.5:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
30. PPR5:​Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
31. HSP70:​Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
32. PPR5L:​Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
33. DEPTOR:​Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
34. FKBP12:​Rapamycin:​Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
35. PPR5L|​pho:​Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
36. DEPTOR|​pho:​Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
37. 14-3-3:​Rictor|​T1135_pho:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
38. GTP:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​RhebL1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
39. 4EBP-1:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
40. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
41. Raptor|​S722_pho|​S719_pho|​S721_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
42. FKBP38:​GTP:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​Rheb:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
43. ?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
44. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​Raptor|​S722_pho|​S719_pho|​S721_pho:​S6K1|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
45. 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
46. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
47. 4EBP-1:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
48. PABP:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​eIF3:​eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane

In compartment: Endomembrane

1. Rictor:​Sin1.1:​TSC1:​TSC2:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Endomembrane

In compartment: Mitochondria

1. Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Mitochondria
2. Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​YY1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Mitochondria
3. PGC-1_alpha:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​YY1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Mitochondria
4. PGC-1_alpha:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​YY1:​mLST8:​mTOR|​S2481_pho|​S1261_pho:​mitochondrial genes@Mitochondria

In compartment: Nucleus

1. PML:​mTOR@Nucleus

In compartment: Rab7 vesicular structure

1. GTP:​RagA:​RagB:​RagC:​RagD:​Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Rab7 vesicular structure
2. GTP:​RagA:​RagB:​RagC:​RagD:​Raptor:​Rheb:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Rab7 vesicular structure

Participates in reactions:
As Reactant or Product:

1. FKBP38:​GTP:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​Rheb:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → SREBP@Cell membrane
2. FKBP38:​GTP:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​Rheb:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → Lipin-1|​pho@Cell membrane
3. FKBP38@Cell membrane + Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → FKBP38:​Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
4. GTP:​Rheb@Rab7 vesicular structure + FKBP38:​Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → FKBP38:​GTP:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​Rheb:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
5. FKBP38:​Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → FKBP38:​GTP:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​Rheb:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
6. Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane + FKBP12:​Rapamycin@Cell membrane → FKBP12:​Rapamycin:​Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
7. PA@Cell membrane + Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → PA:​Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
8. PA:​Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → PA@Cell membrane + Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
9. mTOR@Cell membrane → mTOR|​T2446_pho@Cell membrane
10. mTOR@Cell membrane → mTOR|​S1261_pho@Cell membrane
11. mTOR@Cell membrane → mTOR|​S2481_pho|​S1261_pho|​active@Cell membrane
12. Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane + DEPTOR@Cell membrane → DEPTOR:​Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
13. mTOR|​S1261_pho@Cell membrane → mTOR|​S2481_pho|​S1261_pho|​active@Cell membrane
14. mTOR|​S2481_pho|​S1261_pho|​active@Cell membrane + mLST8@Cell membrane → Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
15. DEPTOR:​Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → DEPTOR|​pho:​Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
16. DEPTOR|​pho:​Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane + DEPTOR|​pho@Cell membrane
17. Raptor@Cell membrane → FKBP38:​GTP:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​Rheb:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
18. FKBP38:​GTP:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​Rheb:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane + 4EBP-1:​S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​m7GTP:​mRNA@Cell membrane → 4EBP-1:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
19. 4EBP-1:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​Raptor|​S722_pho|​S719_pho|​S721_pho:​S6K1|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
20. Raptor|​S722_pho|​S719_pho|​S721_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → PABP:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​eIF3:​eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
21. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​Raptor|​S722_pho|​S719_pho|​S721_pho:​S6K1|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → Raptor|​S722_pho|​S719_pho|​S721_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane + 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho@Cell membrane
22. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​Raptor|​S722_pho|​S719_pho|​S721_pho:​S6K1|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → Raptor|​S722_pho|​S719_pho|​S721_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane + S6K1|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho|​active@Cell membrane
23. 4EBP-1:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​Raptor|​S722_pho|​S719_pho|​S721_pho:​S6K1|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
24. PABP:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​eIF3:​eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → 5'cap-eIF4F-eIF4B-eIF3-PABP:​eIF2-GTP_Met-tRNAi_40S@Cell membrane
25. PML@Cell membrane + mTOR@Cell membrane → PML:​mTOR@Cell membrane
26. PML:​mTOR@Cell membrane → PML:​mTOR@Nucleus
27. GTP:​Rheb@Rab7 vesicular structure + FKBP38:​Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → FKBP38:​GTP:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​Rheb:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
28. 4EBP-1:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
29. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane + 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho@Cell membrane
30. SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → mRNA translation@Cell membrane
31. SF2/ASF@Cell membrane + mTOR@Cell membrane → SF2/ASF:​mTOR@Cell membrane
32. SF2/ASF:​mTOR@Cell membrane + 4EBP-1:​eIF4E:​m7GTP:​mRNA@Cell membrane → 4EBP-1:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
33. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → ?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane + 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho@Cell membrane
34. mTOR@Cell membrane + 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA@Cell membrane → 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
35. 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
36. 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
37. ?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → mRNA translation@Cell membrane
38. mTOR|​S2481_pho|​S1261_pho|​active@Cell membrane → mTOR|​S2481_pho|​S1261_pho|​ubi@Cell membrane
39. mTOR|​S2481_pho|​S1261_pho|​ubi@Cell membrane → degraded
40. Raptor@Cell membrane + mLST8@Cell membrane → Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
41. FKBP38:​GTP:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​Rheb:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane + FKBP38:​GTP:​Rheb@Cell membrane
42. Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane + PRAS40@Cell membrane → PRAS40:​mTORC1@Cell membrane
43. PRAS40|​T246_pho:​mTORC1@Cell membrane → PRAS40|​T246_pho@Cell membrane + Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
44. PRAS40|​S221_pho|​S183_pho|​S212_pho:​mTORC1@Cell membrane → PRAS40|​S221_pho|​S183_pho|​S212_pho@Cell membrane + Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
45. Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane + GTP:​RagA:​RagB:​RagC:​RagD@Cell membrane → GTP:​RagA:​RagB:​RagC:​RagD:​mTORC1@Cell membrane
46. GTP:​RagA:​RagB:​RagC:​RagD:​mTORC1@Cell membrane → GTP:​RagA:​RagB:​RagC:​RagD:​Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Rab7 vesicular structure
47. FKBP38:​GTP:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​Rheb:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → mTOR|​S2481_pho|​S1261_pho|​active@Nucleus
48. GTP:​RhebL1@Rab7 vesicular structure + Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → GTP:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​RhebL1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
49. mTOR@Cell membrane → mTOR@ER-Golgi Network
50. FKBP38:​Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → FKBP38:​GTP:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​Rheb:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
51. mTOR@ER-Golgi Network → mTOR|​S2481_pho|​S1261_pho|​active@ER-Golgi Network
52. Rictor:​Sin1.1:​mLST8:​mTOR@Cell membrane → Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
53. TSC1:​TSC2@Endomembrane + Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → Rictor:​Sin1.1:​TSC1:​TSC2:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Endomembrane
54. DEPTOR@Cell membrane + Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → DEPTOR:​Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
55. DEPTOR:​Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → DEPTOR|​pho:​Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
56. DEPTOR|​pho:​Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane + DEPTOR|​pho@Cell membrane
57. Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane + PPR5@Cell membrane → PPR5:​Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
58. Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane + PPR5L@Cell membrane → PPR5L:​Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
59. GTP:​Rheb@Rab7 vesicular structure + GTP:​RagA:​RagB:​RagC:​RagD:​Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Rab7 vesicular structure → GTP:​RagA:​RagB:​RagC:​RagD:​Raptor:​Rheb:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Rab7 vesicular structure
60. PPR5L:​Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → PPR5L|​pho:​Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
61. PPR5L|​pho:​Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → PPR5L|​pho@Cell membrane + Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
62. Rictor@Cell membrane + mLST8@Cell membrane → Rictor:​Sin1.1:​mLST8:​mTOR@Cell membrane
63. mTOR@Cell membrane + Sin1.1@Cell membrane → Rictor:​Sin1.1:​mLST8:​mTOR@Cell membrane
64. Rictor@Cell membrane + mLST8@Cell membrane → Rictor:​Sin1.2:​mLST8:​mTOR@Cell membrane
65. mTOR@Cell membrane + Sin1.2@Cell membrane → Rictor:​Sin1.2:​mLST8:​mTOR@Cell membrane
66. Rictor@Cell membrane + mLST8@Cell membrane → Rictor:​Sin1.5:​mLST8:​mTOR@Cell membrane
67. mTOR@Cell membrane + Sin1.5@Cell membrane → Rictor:​Sin1.5:​mLST8:​mTOR@Cell membrane
68. Rictor:​Sin1.2:​mLST8:​mTOR@Cell membrane → Rictor:​Sin1.2:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
69. Rictor:​Sin1.5:​mLST8:​mTOR@Cell membrane → Rictor:​Sin1.5:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
70. Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane + HSP70@Cell membrane → HSP70:​Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
71. Rictor:​Sin1.5:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane + JNK@Cell membrane → JNK:​Rictor:​Sin1.5:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
72. Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
73. mTOR@Cell membrane → mTOR|​S2448_pho|​T2446_pho@Cell membrane
74. FKBP38:​GTP:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​Rheb:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → Raptor|​S722_pho|​S792_pho|​S719_pho|​S721_pho|​S863_pho@Cell membrane
75. mTOR|​S2481_pho|​S1261_pho|​active@Cell membrane + Tel2@Cell membrane → Tel2:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
76. Rictor:​Sin1.1:​mLST8:​mTOR@Cell membrane + PA@Cell membrane → PA:​Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
77. PA:​Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → PA@Cell membrane + Rictor:​Sin1.1:​mLST8:​mTOR@Cell membrane
78. Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Mitochondria + YY1@Mitochondria → Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​YY1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Mitochondria
79. Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​YY1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Mitochondria + PGC-1_alpha@Mitochondria → PGC-1_alpha:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​YY1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Mitochondria
80. PGC-1_alpha:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​YY1:​mLST8:​mTOR|​S2481_pho|​S1261_pho:​mitochondrial genes@Mitochondria → oxidative phosphorylation_br_tricarboxylic acid cycle_br_uncoupling respiration@Cell membrane
81. PGC-1_alpha:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​YY1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Mitochondria → PGC-1_alpha@Mitochondria + Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​YY1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Mitochondria
82. CLIP-170@Cell membrane + mTOR|​S2481_pho|​S1261_pho|​active@Cell membrane → CLIP-170:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
83. CLIP-170:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → CLIP-170|​pho:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
84. CLIP-170|​pho:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → CLIP-170|​pho@Cell membrane + mTOR|​S2481_pho|​S1261_pho|​active@Cell membrane
85. Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → Rictor|​T1135_pho:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
86. 14-3-3@Cell membrane + Rictor|​T1135_pho:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → 14-3-3:​Rictor|​T1135_pho:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
87. Rictor:​Sin1.1:​mLST8:​mTOR@Cell membrane → Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
88. FKBP38:​Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → FKBP38:​GTP:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​Rheb:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane

As Catalyser:

1. gPPAR_gamma@Nucleus → rPPAR_gamma@Nucleus
2. rPPAR_gamma@Nucleus → PPAR_gamma@Nucleus
3. S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho@Cell membrane → S6K1|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho|​active@Cell membrane
4. S6K1|​S17_pho@Cell membrane → S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho@Cell membrane
5. 4EBP-1@Cell membrane → 4EBP-1|​T37_pho|​T46_pho@Cell membrane
6. mTOR|​S1261_pho@Cell membrane → mTOR|​S2481_pho|​S1261_pho|​active@Cell membrane
7. S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho@Cell membrane → S6K1|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho|​active@Cell membrane
8. 4EBP-1@Cell membrane → 4EBP-1|​T37_pho|​T46_pho@Cell membrane
9. AKT|​T450_pho:​PI3,4,5-P_sub_3@Cell membrane → AKT|​S473_pho|​T450_pho:​PI3,4,5-P_sub_3@Cell membrane
10. gDEPTOR@Nucleus → rDEPTOR@Cell membrane
11. DEPTOR:​Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → DEPTOR|​pho:​Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
12. 4EBP-1|​T37_pho|​T46_pho@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S70_pho@Cell membrane
13. 4EBP-1|​T37_pho|​T46_pho|​S70_pho@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho@Cell membrane
14. eIF4G@Cell membrane → eIF4G|​S1108_pho|​S1148_pho|​S1192_pho@Cell membrane
15. eEF2K|​S500_pho|​active@Cell membrane → eEF2K|​S359_pho|​S500_pho@Cell membrane
16. Ca_sub_2+:​Calmodulin:​eEF2K@Cell membrane → Ca_sub_2+:​Calmodulin:​eEF2K|​S78_pho@Cell membrane
17. r5'-TOP mRNA@Cell membrane → 5'-TOP-derived proteins@Cell membrane
18. 4EBP-1:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​Raptor|​S722_pho|​S719_pho|​S721_pho:​S6K1|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
19. 4EBP-1:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​Raptor|​S722_pho|​S719_pho|​S721_pho:​S6K1|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
20. cdc2:​cyclin B@Cell membrane → cdc2:​cyclin B@Cell membrane
21. GTP:​Rheb@Rab7 vesicular structure + FKBP38:​Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → FKBP38:​GTP:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​Rheb:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
22. 4EBP-1:​eIF4E:​m7GTP:​mRNA@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​eIF4E:​m7GTP:​mRNA@Cell membrane
23. 4EBP-1:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
24. PP2A@Cell membrane → PP2A|​pho@Cell membrane
25. 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
26. 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
27. mTOR|​S2481_pho|​S1261_pho|​ubi@Cell membrane → degraded
28. Pol I:​TIF-1A|​S633_pho|​S649_pho|​S44_pho|​S170_pho|​S172_pho:​TIF-1B/SL1:​UBF|​pho|​ace|​S484_pho|​S388_pho|​hm2:​rDNA@Nucleus → rrRNA@Nucleus
29. URI@Cell membrane → URI|​pho@Cell membrane
30. PRAS40:​mTORC1@Cell membrane → PRAS40|​S221_pho|​S183_pho|​S212_pho:​mTORC1@Cell membrane
31. Raptor@Cell membrane → FKBP38:​GTP:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​Rheb:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
32. S6K2|​S410_pho|​S417_pho|​S423_pho@Nucleus → S6K2|​T228_pho|​T388_pho|​S370_pho|​S410_pho|​S417_pho|​S423_pho|​active@Nucleus
33. DEPTOR:​Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → DEPTOR|​pho:​Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
34. rPDGRF@Nucleus → PDGFR_beta@Cell membrane
35. gPPR5@Nucleus → rPPR5@Cell membrane
36. gSin1@Nucleus → rSin1@Cell membrane
37. PPR5:​Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → degraded
38. PPR5:​Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → degraded
39. PPR5L:​Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → PPR5L|​pho:​Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
40. AKT|​T450_pho:​PI3,4,5-P_sub_3@Cell membrane → AKT|​S473_pho|​T450_pho:​PI3,4,5-P_sub_3@Cell membrane
41. FAK:​Paxillin:​Src@Cell membrane → FAK:​Paxillin|​Y118_pho|​Y31_pho:​Src@Cell membrane
42. Rac@Cell membrane → Rac@Cell membrane
43. PKC_alpha|​T497_pho|​T638_pho@Cell membrane → PKC_alpha|​S657_pho|​T497_pho|​T638_pho|​active@Cell membrane
44. PKC_alpha|​T497_pho@Cell membrane → PKC_alpha|​T497_pho|​T638_pho@Cell membrane
45. AKT@Cell membrane → AKT|​T450_pho@Cell membrane
46. AKT|​T450_pho@Cell membrane → AKT|​S473_pho|​T450_pho|​active@Cell membrane
47. PHLPP@Cell membrane → PHLPP@Cell membrane
48. SGK1@Cell membrane → SGK1|​S422_pho@Cell membrane
49. SGK1@Cell membrane → SGK1|​S422_pho@Cell membrane
50. Stat3|​T705_pho@Cell membrane → Stat3|​T705_pho|​S727_pho@Cell membrane
51. Lipin@Cell membrane → Lipin|​pho@Cell membrane
52. CLIP-170:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → CLIP-170|​pho:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
53. ATG13:​FIP200:​ULK1/2@Cell membrane → ATG13|​pho:​FIP200:​ULK1/2|​pho@Cell membrane
54. ATG13:​FIP200:​ULK1/2@Cell membrane → ATG13|​pho:​FIP200:​ULK1/2|​pho@Cell membrane
55. Rictor:​Sin1.1:​mLST8:​mTOR@Cell membrane → Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
56. FKBP38:​Raptor:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → FKBP38:​GTP:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​Rheb:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
57. PP2A:​alpha-4@Nucleus → (PP2A:​alpha-4|​pho)|​active@Nucleus