Protein GSK3alpha/beta

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Modifications:
In compartment: Cell membrane

1. GSK3alpha/beta@Cell membrane
2. GSK3alpha/beta|​S21/9_pho@Cell membrane

In compartment: Nucleus

1. GSK3alpha/beta@Nucleus

Participates in complexes:
In compartment: Cell membrane

1. Axin:​GSK3alpha/beta@Cell membrane
2. Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta@Cell membrane
3. APC:​CK1:​GSK3alpha/beta@Cell membrane
4. APC:​CK1:​GSK3alpha/beta:​_beta_Catenin@Cell membrane
5. APC|​pho:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta@Cell membrane
6. APC:​Axin:​CK1:​GSK3alpha/beta:​_beta_Catenin@Cell membrane
7. APC:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin@Cell membrane
8. APC|​pho:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin|​S45_pho@Cell membrane
9. APC|​pho:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin|​S45_pho|​S33_pho|​S37_pho|​T41_pho@Cell membrane
10. APC|​pho:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin|​S45_pho|​S33_pho|​S37_pho|​T41_pho|​ubi@Cell membrane
11. Axin:​Dishevelled:​Frizzled :​G proteins:​GSK3alpha/beta:​LRP5/6:​Wnt@Cell membrane
12. Axin:​Dishevelled:​Frizzled :​G proteins:​GSK3alpha/beta:​LRP5/6|​PPPS/TP_pho:​Wnt@Cell membrane
13. Axin:​CK1:​Dishevelled:​Frizzled :​G proteins:​GSK3alpha/beta:​LRP5/6|​PPPS/TP_pho:​Wnt@Cell membrane
14. Axin:​CK1:​Dishevelled:​Frizzled :​G proteins:​GSK3alpha/beta:​LRP5/6|​PPPS/TP_pho|​PPPS/TP_pho:​Wnt@Cell membrane
15. Axin:​CK1:​Dishevelled:​Frizzled :​G proteins:​GSK3alpha/beta:​LRP5/6|​PPPS/TP_pho|​PPPS/TP_pho:​Wnt@Cell membrane

In compartment: Endomembrane

1. Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta:​TSC1:​TSC2|​S1345_pho@Endomembrane
2. Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta:​TSC1:​TSC2|​S1345_pho|​S1337_pho|​S1341_pho@Endomembrane

Participates in reactions:
As Reactant or Product:

1. GSK3alpha/beta|​S21/9_pho@Cell membrane → GSK3alpha/beta@Cell membrane
2. GSK3alpha/beta@Cell membrane → GSK3alpha/beta|​S21/9_pho@Cell membrane
3. APC:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin@Cell membrane → APC|​pho:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin|​S45_pho@Cell membrane
4. APC|​pho:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin|​S45_pho@Cell membrane → APC|​pho:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin|​S45_pho|​S33_pho|​S37_pho|​T41_pho@Cell membrane
5. _beta_Catenin@Cell membrane + APC@Cell membrane → APC:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin@Cell membrane
6. CK1@Cell membrane + _beta_Catenin@Cell membrane → APC:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin@Cell membrane
7. APC|​pho:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin|​S45_pho|​S33_pho|​S37_pho|​T41_pho@Cell membrane → APC|​pho:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin|​S45_pho|​S33_pho|​S37_pho|​T41_pho|​ubi@Cell membrane
8. APC|​pho:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin|​S45_pho|​S33_pho|​S37_pho|​T41_pho|​ubi@Cell membrane → APC|​pho:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta@Cell membrane + _beta_Catenin|​S45_pho|​S33_pho|​S37_pho|​T41_pho|​ubi@Cell membrane
9. Axin:​GSK3alpha/beta@Cell membrane + Dishevelled:​Frizzled :​G proteins:​LRP5/6:​Wnt@Cell membrane → Axin:​Dishevelled:​Frizzled :​G proteins:​GSK3alpha/beta:​LRP5/6:​Wnt@Cell membrane
10. Axin:​Dishevelled:​Frizzled :​G proteins:​GSK3alpha/beta:​LRP5/6:​Wnt@Cell membrane → Axin:​Dishevelled:​Frizzled :​G proteins:​GSK3alpha/beta:​LRP5/6|​PPPS/TP_pho:​Wnt@Cell membrane
11. Axin:​CK1:​Dishevelled:​Frizzled :​G proteins:​GSK3alpha/beta:​LRP5/6|​PPPS/TP_pho:​Wnt@Cell membrane → Axin:​CK1:​Dishevelled:​Frizzled :​G proteins:​GSK3alpha/beta:​LRP5/6|​PPPS/TP_pho|​PPPS/TP_pho:​Wnt@Cell membrane
12. GSK3alpha/beta@Cell membrane + Axin@Cell membrane → Axin:​GSK3alpha/beta@Cell membrane
13. Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta@Cell membrane + APC@Cell membrane → APC:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin@Cell membrane
14. Axin@Cell membrane + Axin:​CK1:​Dishevelled:​Frizzled :​G proteins:​GSK3alpha/beta:​LRP5/6|​PPPS/TP_pho|​PPPS/TP_pho:​Wnt@Cell membrane → Axin:​CK1:​Dishevelled:​Frizzled :​G proteins:​GSK3alpha/beta:​LRP5/6|​PPPS/TP_pho|​PPPS/TP_pho:​Wnt@Cell membrane
15. CK1@Cell membrane + Axin:​Dishevelled:​Frizzled :​G proteins:​GSK3alpha/beta:​LRP5/6|​PPPS/TP_pho:​Wnt@Cell membrane → Axin:​CK1:​Dishevelled:​Frizzled :​G proteins:​GSK3alpha/beta:​LRP5/6|​PPPS/TP_pho:​Wnt@Cell membrane
16. Axin:​GSK3alpha/beta@Cell membrane → Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta@Cell membrane
17. APC:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin@Cell membrane → APC|​pho:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin|​S45_pho@Cell membrane
18. APC:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin@Cell membrane → APC:​Axin:​CK1:​GSK3alpha/beta:​_beta_Catenin@Cell membrane
19. APC:​Axin:​CK1:​GSK3alpha/beta:​_beta_Catenin@Cell membrane → APC:​CK1:​GSK3alpha/beta:​_beta_Catenin@Cell membrane + Axin@Cell membrane
20. APC:​CK1:​GSK3alpha/beta:​_beta_Catenin@Cell membrane → APC:​CK1:​GSK3alpha/beta@Cell membrane + _beta_Catenin@Cell membrane
21. GSK3alpha/beta@Cell membrane → GSK3alpha/beta|​S21/9_pho@Cell membrane
22. GSK3alpha/beta@Cell membrane → GSK3alpha/beta|​S21/9_pho@Cell membrane
23. APC:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin@Cell membrane → APC:​Axin:​CK1:​GSK3alpha/beta:​_beta_Catenin@Cell membrane
24. TSC1:​TSC2|​S1345_pho@Endomembrane + Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta@Cell membrane → Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta:​TSC1:​TSC2|​S1345_pho@Endomembrane
25. Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta:​TSC1:​TSC2|​S1345_pho@Endomembrane → Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta:​TSC1:​TSC2|​S1345_pho|​S1337_pho|​S1341_pho@Endomembrane
26. Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta:​TSC1:​TSC2|​S1345_pho|​S1337_pho|​S1341_pho@Endomembrane → TSC1@Endomembrane + TSC2|​S1345_pho|​S1337_pho|​S1341_pho@Cell membrane
27. Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta:​TSC1:​TSC2|​S1345_pho|​S1337_pho|​S1341_pho@Endomembrane → TSC2|​S1345_pho|​S1337_pho|​S1341_pho@Cell membrane + Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta@Cell membrane

As Catalyser:

1. TSC1:​TSC2@Endomembrane → TSC1|​T357_pho|​T390_pho:​TSC2@Endomembrane
2. NDRG1|​T366_pho|​T328_pho|​S330_pho|​T346_pho|​T356_pho@Nucleus → NDRG1|​T366_pho|​T328_pho|​S330_pho|​T346_pho|​T356_pho|​S342_pho|​S352_pho|​S362_pho@Nucleus
3. eIF2B_epsilon|​S717_pho|​S718_pho|​S544_pho|​active@Cell membrane → eIF2B_epsilon|​S717_pho|​S718_pho|​S540_pho|​S544_pho@Cell membrane
4. TSC1:​TSC2|​S1345_pho@Endomembrane → TSC1:​TSC2|​S1345_pho|​S1337_pho|​S1341_pho@Endomembrane
5. REDD1@Cell membrane → REDD1|​S19_pho|​T23_pho|​T25_pho@Cell membrane
6. APC:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin@Cell membrane → APC|​pho:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin|​S45_pho@Cell membrane
7. APC|​pho:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin|​S45_pho@Cell membrane → APC|​pho:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin|​S45_pho|​S33_pho|​S37_pho|​T41_pho@Cell membrane
8. Axin:​Dishevelled:​Frizzled :​G proteins:​GSK3alpha/beta:​LRP5/6:​Wnt@Cell membrane → Axin:​Dishevelled:​Frizzled :​G proteins:​GSK3alpha/beta:​LRP5/6|​PPPS/TP_pho:​Wnt@Cell membrane
9. Axin:​CK1:​Dishevelled:​Frizzled :​G proteins:​GSK3alpha/beta:​LRP5/6|​PPPS/TP_pho:​Wnt@Cell membrane → Axin:​CK1:​Dishevelled:​Frizzled :​G proteins:​GSK3alpha/beta:​LRP5/6|​PPPS/TP_pho|​PPPS/TP_pho:​Wnt@Cell membrane
10. GSK3alpha/beta@Cell membrane + Axin@Cell membrane → Axin:​GSK3alpha/beta@Cell membrane
11. Axin:​GSK3alpha/beta@Cell membrane → Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta@Cell membrane
12. APC:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin@Cell membrane → APC|​pho:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin|​S45_pho@Cell membrane
13. Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta:​TSC1:​TSC2|​S1345_pho@Endomembrane → Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta:​TSC1:​TSC2|​S1345_pho|​S1337_pho|​S1341_pho@Endomembrane