Protein Axin

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Modifications:
In compartment: Cell membrane

1. Axin@Cell membrane

Participates in complexes:
In compartment: Cell membrane

1. Axin:​GSK3alpha/beta@Cell membrane
2. Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta@Cell membrane
3. APC|​pho:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta@Cell membrane
4. APC:​Axin:​CK1:​GSK3alpha/beta:​_beta_Catenin@Cell membrane
5. APC:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin@Cell membrane
6. APC|​pho:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin|​S45_pho@Cell membrane
7. APC|​pho:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin|​S45_pho|​S33_pho|​S37_pho|​T41_pho@Cell membrane
8. APC|​pho:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin|​S45_pho|​S33_pho|​S37_pho|​T41_pho|​ubi@Cell membrane
9. Axin:​Dishevelled:​Frizzled :​G proteins:​GSK3alpha/beta:​LRP5/6:​Wnt@Cell membrane
10. Axin:​Dishevelled:​Frizzled :​G proteins:​GSK3alpha/beta:​LRP5/6|​PPPS/TP_pho:​Wnt@Cell membrane
11. Axin:​CK1:​Dishevelled:​Frizzled :​G proteins:​GSK3alpha/beta:​LRP5/6|​PPPS/TP_pho:​Wnt@Cell membrane
12. Axin:​CK1:​Dishevelled:​Frizzled :​G proteins:​GSK3alpha/beta:​LRP5/6|​PPPS/TP_pho|​PPPS/TP_pho:​Wnt@Cell membrane
13. Axin:​CK1:​Dishevelled:​Frizzled :​G proteins:​GSK3alpha/beta:​LRP5/6|​PPPS/TP_pho|​PPPS/TP_pho:​Wnt@Cell membrane

In compartment: Endomembrane

1. Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta:​TSC1:​TSC2|​S1345_pho@Endomembrane
2. Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta:​TSC1:​TSC2|​S1345_pho|​S1337_pho|​S1341_pho@Endomembrane

Participates in reactions:
As Reactant or Product:

1. APC:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin@Cell membrane → APC|​pho:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin|​S45_pho@Cell membrane
2. APC|​pho:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin|​S45_pho@Cell membrane → APC|​pho:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin|​S45_pho|​S33_pho|​S37_pho|​T41_pho@Cell membrane
3. _beta_Catenin@Cell membrane + APC@Cell membrane → APC:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin@Cell membrane
4. CK1@Cell membrane + _beta_Catenin@Cell membrane → APC:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin@Cell membrane
5. APC|​pho:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin|​S45_pho|​S33_pho|​S37_pho|​T41_pho@Cell membrane → APC|​pho:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin|​S45_pho|​S33_pho|​S37_pho|​T41_pho|​ubi@Cell membrane
6. APC|​pho:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin|​S45_pho|​S33_pho|​S37_pho|​T41_pho|​ubi@Cell membrane → APC|​pho:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta@Cell membrane + _beta_Catenin|​S45_pho|​S33_pho|​S37_pho|​T41_pho|​ubi@Cell membrane
7. Axin:​GSK3alpha/beta@Cell membrane + Dishevelled:​Frizzled :​G proteins:​LRP5/6:​Wnt@Cell membrane → Axin:​Dishevelled:​Frizzled :​G proteins:​GSK3alpha/beta:​LRP5/6:​Wnt@Cell membrane
8. Axin:​Dishevelled:​Frizzled :​G proteins:​GSK3alpha/beta:​LRP5/6:​Wnt@Cell membrane → Axin:​Dishevelled:​Frizzled :​G proteins:​GSK3alpha/beta:​LRP5/6|​PPPS/TP_pho:​Wnt@Cell membrane
9. Axin:​CK1:​Dishevelled:​Frizzled :​G proteins:​GSK3alpha/beta:​LRP5/6|​PPPS/TP_pho:​Wnt@Cell membrane → Axin:​CK1:​Dishevelled:​Frizzled :​G proteins:​GSK3alpha/beta:​LRP5/6|​PPPS/TP_pho|​PPPS/TP_pho:​Wnt@Cell membrane
10. GSK3alpha/beta@Cell membrane + Axin@Cell membrane → Axin:​GSK3alpha/beta@Cell membrane
11. Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta@Cell membrane + APC@Cell membrane → APC:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin@Cell membrane
12. Axin@Cell membrane + Axin:​CK1:​Dishevelled:​Frizzled :​G proteins:​GSK3alpha/beta:​LRP5/6|​PPPS/TP_pho|​PPPS/TP_pho:​Wnt@Cell membrane → Axin:​CK1:​Dishevelled:​Frizzled :​G proteins:​GSK3alpha/beta:​LRP5/6|​PPPS/TP_pho|​PPPS/TP_pho:​Wnt@Cell membrane
13. CK1@Cell membrane + Axin:​Dishevelled:​Frizzled :​G proteins:​GSK3alpha/beta:​LRP5/6|​PPPS/TP_pho:​Wnt@Cell membrane → Axin:​CK1:​Dishevelled:​Frizzled :​G proteins:​GSK3alpha/beta:​LRP5/6|​PPPS/TP_pho:​Wnt@Cell membrane
14. Axin:​GSK3alpha/beta@Cell membrane → Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta@Cell membrane
15. APC:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin@Cell membrane → APC|​pho:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin|​S45_pho@Cell membrane
16. Axin@Cell membrane → degraded
17. APC:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin@Cell membrane → APC:​Axin:​CK1:​GSK3alpha/beta:​_beta_Catenin@Cell membrane
18. APC:​Axin:​CK1:​GSK3alpha/beta:​_beta_Catenin@Cell membrane → APC:​CK1:​GSK3alpha/beta:​_beta_Catenin@Cell membrane + Axin@Cell membrane
19. APC:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin@Cell membrane → APC:​Axin:​CK1:​GSK3alpha/beta:​_beta_Catenin@Cell membrane
20. TSC1:​TSC2|​S1345_pho@Endomembrane + Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta@Cell membrane → Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta:​TSC1:​TSC2|​S1345_pho@Endomembrane
21. Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta:​TSC1:​TSC2|​S1345_pho@Endomembrane → Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta:​TSC1:​TSC2|​S1345_pho|​S1337_pho|​S1341_pho@Endomembrane
22. Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta:​TSC1:​TSC2|​S1345_pho|​S1337_pho|​S1341_pho@Endomembrane → TSC1@Endomembrane + TSC2|​S1345_pho|​S1337_pho|​S1341_pho@Cell membrane
23. Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta:​TSC1:​TSC2|​S1345_pho|​S1337_pho|​S1341_pho@Endomembrane → TSC2|​S1345_pho|​S1337_pho|​S1341_pho@Cell membrane + Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta@Cell membrane

As Catalyser:

1. APC:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin@Cell membrane → APC|​pho:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin|​S45_pho@Cell membrane
2. APC|​pho:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin|​S45_pho@Cell membrane → APC|​pho:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin|​S45_pho|​S33_pho|​S37_pho|​T41_pho@Cell membrane
3. Axin:​Dishevelled:​Frizzled :​G proteins:​GSK3alpha/beta:​LRP5/6:​Wnt@Cell membrane → Axin:​Dishevelled:​Frizzled :​G proteins:​GSK3alpha/beta:​LRP5/6|​PPPS/TP_pho:​Wnt@Cell membrane
4. Axin:​CK1:​Dishevelled:​Frizzled :​G proteins:​GSK3alpha/beta:​LRP5/6|​PPPS/TP_pho:​Wnt@Cell membrane → Axin:​CK1:​Dishevelled:​Frizzled :​G proteins:​GSK3alpha/beta:​LRP5/6|​PPPS/TP_pho|​PPPS/TP_pho:​Wnt@Cell membrane
5. GSK3alpha/beta@Cell membrane + Axin@Cell membrane → Axin:​GSK3alpha/beta@Cell membrane
6. Axin:​GSK3alpha/beta@Cell membrane → Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta@Cell membrane
7. APC:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin@Cell membrane → APC|​pho:​Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​CK1:​GSK3alpha/beta:​_beta_Catenin|​S45_pho@Cell membrane
8. Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta:​TSC1:​TSC2|​S1345_pho@Endomembrane → Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta:​TSC1:​TSC2|​S1345_pho|​S1337_pho|​S1341_pho@Endomembrane