Protein rpS6/40S subunit map
rpS6 phosphorylation sites have been mapped to five clustered residues that are conserved in metazoans, consisting of Ser235/236/240/244/247, located at the C-terminal part of the protein.
PMID:3403539
While S6K1 phosphorylates rpS6 at Ser235/236/240/244, RSK exclusively phosphorylates rpS6 at Ser235/236.
PMID:17360704
The functional role of rpS6 phosphorylation is poorly understood. Recently, it has been revealed that phosphorylation of rpS6 at Ser235/236 promotes its recuitment to the 7-methylguanosine cap complex.
PMID:17360704
PMID:16166381
Modifications:
In compartment: Cell membrane
  1. rpS6/40S subunit@Cell membrane map
  2. rpS6/40S subunit|​S235_pho|​S236_pho@Cell membrane map
  3. rpS6/40S subunit|​S235_pho|​S236_pho|​S240_pho|​S244_pho|​S247_pho@Cell membrane map
Participates in complexes:
In compartment: Cell membrane
  1. GDP:​eIF2_alpha:​eIF2_beta:​eIF2_gamma:​rpS6/40S subunit|​S235_pho|​S236_pho|​S240_pho|​S244_pho|​S247_pho@Cell membrane map
  2. GDP:​eIF2_alpha:​eIF2_beta:​eIF2_gamma:​eIF3:​rpS6/40S subunit|​S235_pho|​S236_pho|​S240_pho|​S244_pho|​S247_pho@Cell membrane map
  3. GTP:​Met-tRNAi:​eIF2_alpha:​eIF2_beta:​eIF2_gamma:​rpS6/40S subunit|​S235_pho|​S236_pho|​S240_pho|​S244_pho|​S247_pho@Cell membrane map
Participates in reactions:
As Reactant or Product:
  1. rpS6/40S subunit|​S235_pho|​S236_pho|​S240_pho|​S244_pho|​S247_pho@Cell membrane map + GTP:​Met-tRNAi:​eIF2_alpha:​eIF2_beta:​eIF2_gamma@Cell membrane map → map GTP:​Met-tRNAi:​eIF2_alpha:​eIF2_beta:​eIF2_gamma:​rpS6/40S subunit|​S235_pho|​S236_pho|​S240_pho|​S244_pho|​S247_pho@Cell membrane map
  2. GTP:​Met-tRNAi:​eIF2_alpha:​eIF2_beta:​eIF2_gamma:​rpS6/40S subunit|​S235_pho|​S236_pho|​S240_pho|​S244_pho|​S247_pho@Cell membrane map + GDP@Cell membrane map → map GDP:​eIF2_alpha:​eIF2_beta:​eIF2_gamma:​rpS6/40S subunit|​S235_pho|​S236_pho|​S240_pho|​S244_pho|​S247_pho@Cell membrane map + GTP@Cell membrane map
  3. GDP:​eIF2_alpha:​eIF2_beta:​eIF2_gamma:​rpS6/40S subunit|​S235_pho|​S236_pho|​S240_pho|​S244_pho|​S247_pho@Cell membrane map → map GDP:​eIF2_alpha:​eIF2_beta:​eIF2_gamma@Cell membrane map + rpS6/40S subunit|​S235_pho|​S236_pho|​S240_pho|​S244_pho|​S247_pho@Cell membrane map
  4. PABP:​eIF3:​eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane map + GDP:​eIF2_alpha:​eIF2_beta:​eIF2_gamma:​eIF3:​rpS6/40S subunit|​S235_pho|​S236_pho|​S240_pho|​S244_pho|​S247_pho@Cell membrane map → map 5'cap-eIF4F-eIF4B-eIF3-PABP:​eIF2-GTP_Met-tRNAi_40S@Cell membrane map
  5. GDP:​eIF2_alpha:​eIF2_beta:​eIF2_gamma:​rpS6/40S subunit|​S235_pho|​S236_pho|​S240_pho|​S244_pho|​S247_pho@Cell membrane map + eIF3@Cell membrane map → map GDP:​eIF2_alpha:​eIF2_beta:​eIF2_gamma:​eIF3:​rpS6/40S subunit|​S235_pho|​S236_pho|​S240_pho|​S244_pho|​S247_pho@Cell membrane map
  6. rpS6/40S subunit@Cell membrane map → map rpS6/40S subunit|​S235_pho|​S236_pho|​S240_pho|​S244_pho|​S247_pho@Cell membrane map
  7. rpS6/40S subunit@Cell membrane map → map rpS6/40S subunit|​S235_pho|​S236_pho@Cell membrane map
As Catalyser: