Protein ERK1/2

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Modifications:
In compartment: Cell membrane

1. ERK1/2@Cell membrane
2. ERK1/2|​T202_pho|​Y204_pho|​active@Cell membrane

In compartment: Nucleus

1. ERK1/2|​T202_pho|​Y204_pho|​active@Nucleus

Participates in complexes:
In compartment: Cell membrane

1. ERK1/2:​RSK1/2@Cell membrane
2. ERK1/2:​RSK1/2|​S154_pho@Cell membrane
3. 14-3-3_beta:​ERK1/2:​RSK1/2|​S154_pho@Cell membrane
4. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S154_pho@Cell membrane
5. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S352_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane
6. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S352_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane
7. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S352_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane
8. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane
9. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane
10. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​T348_pho|​S721_pho@Cell membrane
11. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho|​S721_pho@Cell membrane

Participates in reactions:
As Reactant or Product:

1. GRB2, SOS,_br_Ras, Raf, MEK@Cell membrane → ERK1/2@Cell membrane
2. ERK1/2:​RSK1/2@Cell membrane → ERK1/2:​RSK1/2|​S154_pho@Cell membrane
3. ERK1/2:​RSK1/2|​S154_pho@Cell membrane + 14-3-3_beta@Cell membrane → 14-3-3_beta:​ERK1/2:​RSK1/2|​S154_pho@Cell membrane
4. 14-3-3_beta:​ERK1/2:​RSK1/2|​S154_pho@Cell membrane → 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S154_pho@Cell membrane
5. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S154_pho@Cell membrane → 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S352_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane
6. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S352_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane → 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S352_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane
7. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S352_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane → 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S352_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane
8. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S352_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane + PDK1@Cell membrane → 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane
9. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane → 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane
10. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane → 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho|​S721_pho@Cell membrane
11. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho|​S721_pho@Cell membrane → ERK1/2|​T202_pho|​Y204_pho|​active@Cell membrane + RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​T348_pho|​S721_pho|​active@Cell membrane
12. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho|​S721_pho@Cell membrane → RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​T348_pho|​S721_pho|​active@Cell membrane + PDK1:​PI3,4,5-P_sub_3@Cell membrane
13. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​T348_pho|​S721_pho@Cell membrane → 14-3-3_beta@Cell membrane + RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​T348_pho|​S721_pho|​active@Cell membrane
14. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho|​S721_pho@Cell membrane → 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​T348_pho|​S721_pho@Cell membrane
15. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S352_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane → 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S352_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane
16. ERK1/2@Cell membrane + RSK1/2@Cell membrane → ERK1/2:​RSK1/2@Cell membrane
17. ERK1/2|​T202_pho|​Y204_pho|​active@Cell membrane → Mnk1/2@Cell membrane
18. ERK1/2|​T202_pho|​Y204_pho|​active@Cell membrane → ERK1/2|​T202_pho|​Y204_pho|​active@Nucleus

As Catalyser:

1. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S154_pho@Cell membrane → 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S352_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane
2. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S352_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane → 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S352_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane
3. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane → 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane
4. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane → 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho|​S721_pho@Cell membrane
5. TSC1:​TSC2@Endomembrane → TSC1:​TSC2|​S664_pho@Endomembrane
6. Pol I:​TIF-1A|​S649_pho|​S44_pho|​S170_pho|​S172_pho:​TIF-1B/SL1:​UBF|​pho|​ace|​S484_pho|​S388_pho|​hm2:​rDNA@Nucleus → Pol I:​TIF-1A|​S633_pho|​S649_pho|​S44_pho|​S170_pho|​S172_pho:​TIF-1B/SL1:​UBF|​pho|​ace|​S484_pho|​S388_pho|​hm2:​rDNA@Nucleus