Protein PDK1

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Modifications:
In compartment: Cell membrane

1. PDK1@Cell membrane
2. PDK1@Cell membrane

Participates in complexes:
In compartment: Cell membrane

1. PDK1:​PI3,4,5-P_sub_3@Cell membrane
2. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane
3. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane
4. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​T348_pho|​S721_pho@Cell membrane
5. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho|​S721_pho@Cell membrane

Participates in reactions:
As Reactant or Product:

1. PDK1@Cell membrane → PDK1@Cell membrane
2. PI3,4,5-P_sub_3@Cell membrane + PDK1@Cell membrane → PDK1:​PI3,4,5-P_sub_3@Cell membrane
3. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S352_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane + PDK1@Cell membrane → 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane
4. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane → 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane
5. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane → 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho|​S721_pho@Cell membrane
6. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho|​S721_pho@Cell membrane → ERK1/2|​T202_pho|​Y204_pho|​active@Cell membrane + RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​T348_pho|​S721_pho|​active@Cell membrane
7. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho|​S721_pho@Cell membrane → RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​T348_pho|​S721_pho|​active@Cell membrane + PDK1:​PI3,4,5-P_sub_3@Cell membrane
8. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​T348_pho|​S721_pho@Cell membrane → 14-3-3_beta@Cell membrane + RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​T348_pho|​S721_pho|​active@Cell membrane
9. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho|​S721_pho@Cell membrane → 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​T348_pho|​S721_pho@Cell membrane
10. PDK1@Cell membrane → PDK1@Cell membrane

As Catalyser:

1. S6K1|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho|​active@Cell membrane → S6K1|​T229_pho|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho|​active@Cell membrane
2. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane → 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane
3. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane → 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho|​S721_pho@Cell membrane
4. AKT|​S473_pho|​T450_pho:​PI3,4,5-P_sub_3@Cell membrane → AKT|​T308_pho|​S473_pho|​T450_pho:​PI3,4,5-P_sub_3@Cell membrane
5. PKC_alpha@Cell membrane → PKC_alpha|​T497_pho@Cell membrane
6. PKC_alpha|​T497_pho@Cell membrane → PKC_alpha|​T497_pho|​T638_pho@Cell membrane
7. gPKC_alpha@Nucleus → rPKC_alpha@Cell membrane
8. AKT|​T450_pho:​PI3,4,5-P_sub_3@Cell membrane → AKT|​T308_pho|​T450_pho:​PI3,4,5-P_sub_3@Cell membrane
9. SGK1|​S422_pho@Cell membrane → SGK1|​T256_pho|​S422_pho|​active@Cell membrane