Protein RSK1/2
PMID:18508509
RSK1 (human) phosphorylation sites:
S221, T359, S363, S380, T573, S732
RSK1 (mouse) phosphorylation sites:
S221, T348, S352, S369, T562, S721
RSK2 (human) phosphorylation sites:
S227, T365, S369, S386, T577, S737

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Modifications:
In compartment: Cell membrane

1. RSK1/2@Cell membrane
2. RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​T348_pho|​S721_pho|​active@Cell membrane

In compartment: Nucleus

1. RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​T348_pho|​S721_pho|​active@Nucleus

Participates in complexes:
In compartment: Cell membrane

1. ERK1/2:​RSK1/2@Cell membrane
2. ERK1/2:​RSK1/2|​S154_pho@Cell membrane
3. 14-3-3_beta:​ERK1/2:​RSK1/2|​S154_pho@Cell membrane
4. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S154_pho@Cell membrane
5. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S352_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane
6. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S352_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane
7. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S352_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane
8. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane
9. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane
10. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​T348_pho|​S721_pho@Cell membrane
11. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho|​S721_pho@Cell membrane

Participates in reactions:
As Reactant or Product:

1. ERK1/2:​RSK1/2@Cell membrane → ERK1/2:​RSK1/2|​S154_pho@Cell membrane
2. ERK1/2:​RSK1/2|​S154_pho@Cell membrane + 14-3-3_beta@Cell membrane → 14-3-3_beta:​ERK1/2:​RSK1/2|​S154_pho@Cell membrane
3. 14-3-3_beta:​ERK1/2:​RSK1/2|​S154_pho@Cell membrane → 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S154_pho@Cell membrane
4. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S154_pho@Cell membrane → 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S352_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane
5. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S352_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane → 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S352_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane
6. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S352_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane → 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S352_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane
7. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S352_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane + PDK1@Cell membrane → 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane
8. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane → 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane
9. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane → 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho|​S721_pho@Cell membrane
10. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho|​S721_pho@Cell membrane → ERK1/2|​T202_pho|​Y204_pho|​active@Cell membrane + RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​T348_pho|​S721_pho|​active@Cell membrane
11. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho|​S721_pho@Cell membrane → RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​T348_pho|​S721_pho|​active@Cell membrane + PDK1:​PI3,4,5-P_sub_3@Cell membrane
12. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​T348_pho|​S721_pho@Cell membrane → 14-3-3_beta@Cell membrane + RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​T348_pho|​S721_pho|​active@Cell membrane
13. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho|​S721_pho@Cell membrane → 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​T348_pho|​S721_pho@Cell membrane
14. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S352_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane → 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S352_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane
15. ERK1/2@Cell membrane + RSK1/2@Cell membrane → ERK1/2:​RSK1/2@Cell membrane
16. RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​T348_pho|​S721_pho|​active@Cell membrane → RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​T348_pho|​S721_pho|​active@Nucleus
17. RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​T348_pho|​S721_pho|​active@Nucleus → Gene transcription@Nucleus
18. RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​T348_pho|​S721_pho|​active@Cell membrane → Proliferation_br_survival/apoptosis@Cell membrane
19. RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​T348_pho|​S721_pho|​active@Cell membrane → RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​T348_pho|​S721_pho|​active@Nucleus

As Catalyser:

1. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S154_pho@Cell membrane → 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S352_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane
2. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S352_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane → 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​RSK1/2|​S352_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane
3. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane → 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane
4. 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho@Cell membrane → 14-3-3_beta:​ERK1/2|​T202_pho|​Y204_pho:​PDK1:​RSK1/2|​S352_pho|​S221_pho|​S369_pho|​T562_pho|​S154_pho|​T348_pho|​S721_pho@Cell membrane
5. Raptor@Cell membrane → FKBP38:​GTP:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​Rheb:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
6. TSC1:​TSC2@Endomembrane → TSC1:​TSC2|​S1798_pho@Endomembrane
7. TSC2@Cell membrane → TSC2|​S1798_pho@Nucleus
8. eIF4B@Cell membrane → eIF4B|​S422_pho@Cell membrane
9. eEF2K|​S500_pho|​active@Cell membrane → eEF2K|​S366_pho|​S500_pho@Cell membrane
10. rpS6/40S subunit@Cell membrane → rpS6/40S subunit|​S235_pho|​S236_pho@Cell membrane
11. GSK3alpha/beta@Cell membrane → GSK3alpha/beta|​S21/9_pho@Cell membrane
12. Pol I:​TIF-1A|​S44_pho|​S170_pho|​S172_pho:​TIF-1B/SL1:​UBF|​pho|​ace|​S484_pho|​S388_pho|​hm2:​rDNA@Nucleus → Pol I:​TIF-1A|​S649_pho|​S44_pho|​S170_pho|​S172_pho:​TIF-1B/SL1:​UBF|​pho|​ace|​S484_pho|​S388_pho|​hm2:​rDNA@Nucleus
13. CCT_alpha:​CCT_beta:​CCT_delta:​CCT_epsilon:​CCT_eta:​CCT_gamma:​CCT_theta:​CCT_zeta@Cell membrane → CCT_alpha:​CCT_beta|​S260_pho:​CCT_delta:​CCT_epsilon:​CCT_eta:​CCT_gamma:​CCT_theta:​CCT_zeta@Cell membrane