Protein NF-_kappa_ B_br_(p50)

---

Modifications:
In compartment: cytosol

1. NF-_kappa_ B_br_(p50)@cytosol
2. NF-_kappa_ B_br_(p50)|​S337_pho|​hm2@cytosol

In compartment: unknown

1. NF-_kappa_ B_br_(p50)@unknown
2. NF-_kappa_ B_br_(p50)|​S337_pho|​hm2@unknown

Participates in complexes:
In compartment: cytosol

1. NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol
2. NF-_kappa_ B1_br_(p105):​NF-_kappa_ B_br_(p50)@cytosol
3. NF-_kappa_ B_br_ (p65)|​S276_pho:​NF-_kappa_ B_br_(p50)@cytosol
4. Bcl-3:​NF-_kappa_ B_br_(p50)|​S337_pho|​hm2@cytosol
5. I_kappa_ B_beta:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol
6. I_kappa_ B_alpha:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol
7. NF-_kappa_ B_br_ (p65)|​S276_unk:​NF-_kappa_ B_br_(p50):​PKAc@cytosol
8. I_kappa_ B_beta|​S19_pho|​S23_pho:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol
9. I_kappa_ B_alpha|​S32_pho|​S36_pho:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol
10. I_kappa_ B_beta|​S19_pho|​S23_pho|​ubi:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol
11. I_kappa_ B_alpha|​S32_pho|​S36_pho|​K21_ubi|​K22_ubi:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol
12. I_kappa_ B_alpha:​NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk:​NF-_kappa_ B_br_(p50)@cytosol
13. I_kappa_ B_alpha__br_I_kappa_ B_beta:​NF-_kappa_ B_br_ (p65)|​S276_unk:​NF-_kappa_ B_br_(p50):​PKAc@cytosol

In compartment: unknown

1. Bcl-3:​NF-_kappa_ B_br_(p50)|​S337_pho|​hm2@unknown
2. NF-_kappa_ B_br_(p50)|​S337_pho|​hm2:​_kappa_ B site@unknown
3. (I_kappa_ B_zeta:​NF-_kappa_ B_br_(p50)|​S337_pho|​hm2)|​active@unknown
4. (NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_pho|​S536_pho|​S529_pho:​NF-_kappa_ B_br_(p50))|​active@unknown
5. (NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_pho|​S536_pho|​S529_pho|​K218_ace|​K221_ace|​K310_ace:​NF-_kappa_ B_br_(p50))|​active@unknown
6. NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_pho|​S536_pho|​S529_pho|​K123_ace|​K218_ace|​K221_ace|​K310_ace|​K122_ace:​NF-_kappa_ B_br_(p50)@unknown
7. I_kappa_ B_alpha|​S32_pho|​S36_pho:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@unknown
8. I_kappa_ B_alpha|​S32_pho|​S36_pho|​K21_ubi|​K22_ubi:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@unknown
9. I_kappa_ B_alpha:​NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk:​NF-_kappa_ B_br_(p50)@unknown
10. I_kappa_ B_beta|​S313_pho|​S315_pho:​NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk:​NF-_kappa_ B_br_(p50)@unknown
11. CBP:​NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk|​K218_ace|​K221_ace|​K310_ace:​NF-_kappa_ B_br_(p50):​_kappa_ B site@unknown

Participates in reactions:
As Reactant or Product:

1. rNF-_kappa_ B1@cytosol → NF-_kappa_ B_br_(p50)@cytosol
2. NF-_kappa_ B_br_(p50)@cytosol → NF-_kappa_ B_br_(p50)|​S337_pho|​hm2@cytosol
3. NF-_kappa_ B1_br_(p105)@cytosol → NF-_kappa_ B_br_(p50)@cytosol + degraded
4. NF-_kappa_ B1_br_(p105)@cytosol + NF-_kappa_ B_br_(p50)@cytosol → NF-_kappa_ B1_br_(p105):​NF-_kappa_ B_br_(p50)@cytosol
5. NF-_kappa_ B1_br_(p105):​NF-_kappa_ B_br_(p50)@cytosol → NF-_kappa_ B_br_(p50)@cytosol + NF-_kappa_ B1_br_(p105)@cytosol
6. NF-_kappa_ B1_br_(p105)|​S923_pho|​ubi|​S927_pho@cytosol → NF-_kappa_ B_br_(p50)@cytosol + degraded
7. NF-_kappa_ B_br_(p50)@cytosol + NF-_kappa_ B_br_ (p65)@cytosol + I_kappa_ B_alpha@cytosol → I_kappa_ B_alpha:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol
8. I_kappa_ B_alpha:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol → I_kappa_ B_alpha|​S32_pho|​S36_pho:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol
9. I_kappa_ B_alpha|​S32_pho|​S36_pho:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol → I_kappa_ B_alpha|​S32_pho|​S36_pho:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@unknown
10. I_kappa_ B_alpha|​S32_pho|​S36_pho:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@unknown → I_kappa_ B_alpha|​S32_pho|​S36_pho|​K21_ubi|​K22_ubi:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@unknown
11. I_kappa_ B_alpha|​S32_pho|​S36_pho|​K21_ubi|​K22_ubi:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@unknown → I_kappa_ B_alpha|​S32_pho|​S36_pho|​K21_ubi|​K22_ubi:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol
12. I_kappa_ B_alpha|​S32_pho|​S36_pho:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol → I_kappa_ B_alpha|​S32_pho|​S36_pho|​K21_ubi|​K22_ubi:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol
13. I_kappa_ B_alpha|​S32_pho|​S36_pho|​K21_ubi|​K22_ubi:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol → NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol + I_kappa_ B_alpha|​S32_pho|​S36_pho|​K21_ubi|​K22_ubi@cytosol
14. I_kappa_ B_alpha__br_I_kappa_ B_beta:​NF-_kappa_ B_br_ (p65)|​S276_unk:​NF-_kappa_ B_br_(p50):​PKAc@cytosol → NF-_kappa_ B_br_ (p65)|​S276_unk:​NF-_kappa_ B_br_(p50):​PKAc@cytosol + I_kappa_ B_alpha__br_I_kappa_ B_beta|​pho|​pho|​ubi|​ubi@cytosol
15. NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol → (NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_pho|​S536_pho|​S529_pho:​NF-_kappa_ B_br_(p50))|​active@unknown
16. NF-_kappa_ B_br_ (p65)|​S276_pho:​NF-_kappa_ B_br_(p50)@cytosol → (NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_pho|​S536_pho|​S529_pho:​NF-_kappa_ B_br_(p50))|​active@unknown
17. NF-_kappa_ B_br_(p50)@cytosol + NF-_kappa_ B_br_ (p65)@cytosol + I_kappa_ B_beta@cytosol → I_kappa_ B_beta:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol
18. I_kappa_ B_beta:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol → I_kappa_ B_beta|​S19_pho|​S23_pho:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol
19. I_kappa_ B_beta|​S19_pho|​S23_pho:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol → I_kappa_ B_beta|​S19_pho|​S23_pho|​ubi:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol
20. I_kappa_ B_beta|​S19_pho|​S23_pho|​ubi:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol → I_kappa_ B_beta|​S19_pho|​S23_pho|​ubi@cytosol + NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol
21. (NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_pho|​S536_pho|​S529_pho:​NF-_kappa_ B_br_(p50))|​active@unknown + I_kappa_ B_beta|​S313_pho|​S315_pho@unknown → I_kappa_ B_beta|​S313_pho|​S315_pho:​NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk:​NF-_kappa_ B_br_(p50)@unknown
22. (NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_pho|​S536_pho|​S529_pho:​NF-_kappa_ B_br_(p50))|​active@unknown + I_kappa_ B_alpha@unknown → I_kappa_ B_alpha:​NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk:​NF-_kappa_ B_br_(p50)@unknown
23. I_kappa_ B_alpha:​NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk:​NF-_kappa_ B_br_(p50)@unknown → I_kappa_ B_alpha:​NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk:​NF-_kappa_ B_br_(p50)@cytosol
24. I_kappa_ B_alpha:​NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk:​NF-_kappa_ B_br_(p50)@cytosol → I_kappa_ B_alpha:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol
25. NF-_kappa_ B_br_(p50)@cytosol + NF-_kappa_ B_br_ (p65)@cytosol + I_kappa_ B_alpha@cytosol + I_kappa_ B_beta@cytosol + PKAc@cytosol → I_kappa_ B_alpha__br_I_kappa_ B_beta:​NF-_kappa_ B_br_ (p65)|​S276_unk:​NF-_kappa_ B_br_(p50):​PKAc@cytosol
26. NF-_kappa_ B_br_(p50)|​S337_pho|​hm2@cytosol → NF-_kappa_ B_br_(p50)|​S337_pho|​hm2@unknown
27. (NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_pho|​S536_pho|​S529_pho:​NF-_kappa_ B_br_(p50))|​active@unknown → (NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_pho|​S536_pho|​S529_pho|​K218_ace|​K221_ace|​K310_ace:​NF-_kappa_ B_br_(p50))|​active@unknown
28. CBP:​NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk|​K218_ace|​K221_ace|​K310_ace:​NF-_kappa_ B_br_(p50):​_kappa_ B site@unknown → target genes_br_ex. IL-1, IL-8, IL-6, TNF_alpha_ , IFN_gamma_ , GM-CSF, M-CSF,_br_iNOS, COX2, MHC class I / II, E-selectin, _beta_ -defensin2@unknown
29. CBP:​NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk|​K218_ace|​K221_ace|​K310_ace:​NF-_kappa_ B_br_(p50):​_kappa_ B site@unknown → NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk|​K123_unk|​K218_unk|​K221_unk|​K310_unk@unknown + g_kappa_ B site@unknown + NF-_kappa_ B_br_(p50)@unknown + CBP@unknown
30. (NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_pho|​S536_pho|​S529_pho|​K218_ace|​K221_ace|​K310_ace:​NF-_kappa_ B_br_(p50))|​active@unknown → (NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_pho|​S536_pho|​S529_pho:​NF-_kappa_ B_br_(p50))|​active@unknown
31. (NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_pho|​S536_pho|​S529_pho|​K218_ace|​K221_ace|​K310_ace:​NF-_kappa_ B_br_(p50))|​active@unknown → NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_pho|​S536_pho|​S529_pho|​K123_ace|​K218_ace|​K221_ace|​K310_ace|​K122_ace:​NF-_kappa_ B_br_(p50)@unknown
32. NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_pho|​S536_pho|​S529_pho|​K123_ace|​K218_ace|​K221_ace|​K310_ace|​K122_ace:​NF-_kappa_ B_br_(p50)@unknown → (NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_pho|​S536_pho|​S529_pho|​K218_ace|​K221_ace|​K310_ace:​NF-_kappa_ B_br_(p50))|​active@unknown
33. CBP:​NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk|​K218_ace|​K221_ace|​K310_ace:​NF-_kappa_ B_br_(p50):​_kappa_ B site@unknown → NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_pho|​S536_pho|​S529_pho|​K123_ace|​K218_ace|​K221_ace|​K310_ace|​K122_ace:​NF-_kappa_ B_br_(p50)@unknown + g_kappa_ B site@unknown + CBP@unknown
34. (NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_pho|​S536_pho|​S529_pho|​K218_ace|​K221_ace|​K310_ace:​NF-_kappa_ B_br_(p50))|​active@unknown + CBP@unknown + g_kappa_ B site@unknown → CBP:​NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk|​K218_ace|​K221_ace|​K310_ace:​NF-_kappa_ B_br_(p50):​_kappa_ B site@unknown
35. NF-_kappa_ B_br_(p50)|​S337_pho|​hm2@unknown + I_kappa_ B_zeta@unknown → (I_kappa_ B_zeta:​NF-_kappa_ B_br_(p50)|​S337_pho|​hm2)|​active@unknown
36. Bcl-3@cytosol + NF-_kappa_ B_br_(p50)|​S337_pho|​hm2@cytosol → Bcl-3:​NF-_kappa_ B_br_(p50)|​S337_pho|​hm2@cytosol
37. Bcl-3:​NF-_kappa_ B_br_(p50)|​S337_pho|​hm2@cytosol → Bcl-3:​NF-_kappa_ B_br_(p50)|​S337_pho|​hm2@unknown
38. Bcl-3:​NF-_kappa_ B_br_(p50)|​S337_pho|​hm2@unknown → target gene_br_ex. Bcl-2@unknown
39. NF-_kappa_ B_br_(p50)|​S337_pho|​hm2@unknown + g_kappa_ B site@unknown → NF-_kappa_ B_br_(p50)|​S337_pho|​hm2:​_kappa_ B site@unknown
40. NF-_kappa_ B_br_(p50)|​S337_pho|​hm2:​_kappa_ B site@unknown + Bcl-3@unknown → Bcl-3:​NF-_kappa_ B_br_(p50)|​S337_pho|​hm2@unknown + g_kappa_ B site@unknown
41. CBP:​NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk|​K218_ace|​K221_ace|​K310_ace:​NF-_kappa_ B_br_(p50):​_kappa_ B site@unknown → gIL-1_alpha@unknown
42. CBP:​NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk|​K218_ace|​K221_ace|​K310_ace:​NF-_kappa_ B_br_(p50):​_kappa_ B site@unknown → gIL-1_beta@unknown
43. CBP:​NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk|​K218_ace|​K221_ace|​K310_ace:​NF-_kappa_ B_br_(p50):​_kappa_ B site@unknown → gIL-1ra@unknown
44. NF-_kappa_ B_br_ (p65)|​S276_unk:​NF-_kappa_ B_br_(p50):​PKAc@cytosol → NF-_kappa_ B_br_ (p65)|​S276_pho:​NF-_kappa_ B_br_(p50)@cytosol + PKAc@cytosol

As Catalyser:

1. CBP:​NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk|​K218_ace|​K221_ace|​K310_ace:​NF-_kappa_ B_br_(p50):​_kappa_ B site@unknown → NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_pho|​S536_pho|​S529_pho|​K123_ace|​K218_ace|​K221_ace|​K310_ace|​K122_ace:​NF-_kappa_ B_br_(p50)@unknown + g_kappa_ B site@unknown + CBP@unknown
2. HDAC-1@unknown → HDAC-1*@unknown
3. gA20@unknown → rA20@unknown
4. gNF-_kappa_ B1@unknown → rNF-_kappa_ B1@cytosol
5. gI_kappa_ B_alpha@unknown → rI_kappa_ B_alpha@unknown
6. gIL-6@unknown → rIL-6@unknown
7. gelk-1@unknown → Elk-1@unknown
8. NF-_kappa_ B_br_ (p65)|​S276_unk:​NF-_kappa_ B_br_(p50):​PKAc@cytosol → NF-_kappa_ B_br_ (p65)|​S276_pho:​NF-_kappa_ B_br_(p50)@cytosol + PKAc@cytosol