Protein NF-_kappa_ B_br_ (p65)

---

Modifications:
In compartment: cytosol

1. NF-_kappa_ B_br_ (p65)@cytosol

In compartment: unknown

1. NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk|​K123_unk|​K218_unk|​K221_unk|​K310_unk@unknown
2. NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​ubi|​S529_unk|​K123_unk|​K218_unk|​K221_unk|​K310_unk@unknown

Participates in complexes:
In compartment: cytosol

1. NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol
2. NF-_kappa_ B_br_ (p65)|​S276_pho:​NF-_kappa_ B_br_(p50)@cytosol
3. I_kappa_ B_beta:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol
4. I_kappa_ B_alpha:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol
5. NF-_kappa_ B_br_ (p65)|​S276_unk:​NF-_kappa_ B_br_(p50):​PKAc@cytosol
6. I_kappa_ B_beta|​S19_pho|​S23_pho:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol
7. I_kappa_ B_alpha|​S32_pho|​S36_pho:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol
8. I_kappa_ B_beta|​S19_pho|​S23_pho|​ubi:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol
9. I_kappa_ B_alpha|​S32_pho|​S36_pho|​K21_ubi|​K22_ubi:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol
10. I_kappa_ B_alpha:​NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk:​NF-_kappa_ B_br_(p50)@cytosol
11. I_kappa_ B_alpha__br_I_kappa_ B_beta:​NF-_kappa_ B_br_ (p65)|​S276_unk:​NF-_kappa_ B_br_(p50):​PKAc@cytosol

In compartment: unknown

1. (NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_pho|​S536_pho|​S529_pho:​NF-_kappa_ B_br_(p50))|​active@unknown
2. (NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_pho|​S536_pho|​S529_pho|​K218_ace|​K221_ace|​K310_ace:​NF-_kappa_ B_br_(p50))|​active@unknown
3. NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_pho|​S536_pho|​S529_pho|​K123_ace|​K218_ace|​K221_ace|​K310_ace|​K122_ace:​NF-_kappa_ B_br_(p50)@unknown
4. I_kappa_ B_alpha|​S32_pho|​S36_pho:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@unknown
5. I_kappa_ B_alpha|​S32_pho|​S36_pho|​K21_ubi|​K22_ubi:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@unknown
6. I_kappa_ B_alpha:​NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk:​NF-_kappa_ B_br_(p50)@unknown
7. I_kappa_ B_beta|​S313_pho|​S315_pho:​NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk:​NF-_kappa_ B_br_(p50)@unknown
8. CBP:​NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk|​K218_ace|​K221_ace|​K310_ace:​NF-_kappa_ B_br_(p50):​_kappa_ B site@unknown

Participates in reactions:
As Reactant or Product:

1. NF-_kappa_ B_br_ (p65)@cytosol → degraded
2. NF-_kappa_ B_br_(p50)@cytosol + NF-_kappa_ B_br_ (p65)@cytosol + I_kappa_ B_alpha@cytosol → I_kappa_ B_alpha:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol
3. I_kappa_ B_alpha:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol → I_kappa_ B_alpha|​S32_pho|​S36_pho:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol
4. I_kappa_ B_alpha|​S32_pho|​S36_pho:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol → I_kappa_ B_alpha|​S32_pho|​S36_pho:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@unknown
5. I_kappa_ B_alpha|​S32_pho|​S36_pho:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@unknown → I_kappa_ B_alpha|​S32_pho|​S36_pho|​K21_ubi|​K22_ubi:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@unknown
6. I_kappa_ B_alpha|​S32_pho|​S36_pho|​K21_ubi|​K22_ubi:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@unknown → I_kappa_ B_alpha|​S32_pho|​S36_pho|​K21_ubi|​K22_ubi:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol
7. I_kappa_ B_alpha|​S32_pho|​S36_pho:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol → I_kappa_ B_alpha|​S32_pho|​S36_pho|​K21_ubi|​K22_ubi:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol
8. I_kappa_ B_alpha|​S32_pho|​S36_pho|​K21_ubi|​K22_ubi:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol → NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol + I_kappa_ B_alpha|​S32_pho|​S36_pho|​K21_ubi|​K22_ubi@cytosol
9. I_kappa_ B_alpha__br_I_kappa_ B_beta:​NF-_kappa_ B_br_ (p65)|​S276_unk:​NF-_kappa_ B_br_(p50):​PKAc@cytosol → NF-_kappa_ B_br_ (p65)|​S276_unk:​NF-_kappa_ B_br_(p50):​PKAc@cytosol + I_kappa_ B_alpha__br_I_kappa_ B_beta|​pho|​pho|​ubi|​ubi@cytosol
10. NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol → (NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_pho|​S536_pho|​S529_pho:​NF-_kappa_ B_br_(p50))|​active@unknown
11. NF-_kappa_ B_br_ (p65)|​S276_pho:​NF-_kappa_ B_br_(p50)@cytosol → (NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_pho|​S536_pho|​S529_pho:​NF-_kappa_ B_br_(p50))|​active@unknown
12. NF-_kappa_ B_br_(p50)@cytosol + NF-_kappa_ B_br_ (p65)@cytosol + I_kappa_ B_beta@cytosol → I_kappa_ B_beta:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol
13. I_kappa_ B_beta:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol → I_kappa_ B_beta|​S19_pho|​S23_pho:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol
14. I_kappa_ B_beta|​S19_pho|​S23_pho:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol → I_kappa_ B_beta|​S19_pho|​S23_pho|​ubi:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol
15. I_kappa_ B_beta|​S19_pho|​S23_pho|​ubi:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol → I_kappa_ B_beta|​S19_pho|​S23_pho|​ubi@cytosol + NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol
16. NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk|​K123_unk|​K218_unk|​K221_unk|​K310_unk@unknown → NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​ubi|​S529_unk|​K123_unk|​K218_unk|​K221_unk|​K310_unk@unknown
17. NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​ubi|​S529_unk|​K123_unk|​K218_unk|​K221_unk|​K310_unk@unknown → degraded
18. (NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_pho|​S536_pho|​S529_pho:​NF-_kappa_ B_br_(p50))|​active@unknown + I_kappa_ B_beta|​S313_pho|​S315_pho@unknown → I_kappa_ B_beta|​S313_pho|​S315_pho:​NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk:​NF-_kappa_ B_br_(p50)@unknown
19. (NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_pho|​S536_pho|​S529_pho:​NF-_kappa_ B_br_(p50))|​active@unknown + I_kappa_ B_alpha@unknown → I_kappa_ B_alpha:​NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk:​NF-_kappa_ B_br_(p50)@unknown
20. I_kappa_ B_alpha:​NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk:​NF-_kappa_ B_br_(p50)@unknown → I_kappa_ B_alpha:​NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk:​NF-_kappa_ B_br_(p50)@cytosol
21. I_kappa_ B_alpha:​NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk:​NF-_kappa_ B_br_(p50)@cytosol → I_kappa_ B_alpha:​NF-_kappa_ B_br_ (p65):​NF-_kappa_ B_br_(p50)@cytosol
22. NF-_kappa_ B_br_(p50)@cytosol + NF-_kappa_ B_br_ (p65)@cytosol + I_kappa_ B_alpha@cytosol + I_kappa_ B_beta@cytosol + PKAc@cytosol → I_kappa_ B_alpha__br_I_kappa_ B_beta:​NF-_kappa_ B_br_ (p65)|​S276_unk:​NF-_kappa_ B_br_(p50):​PKAc@cytosol
23. (NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_pho|​S536_pho|​S529_pho:​NF-_kappa_ B_br_(p50))|​active@unknown → (NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_pho|​S536_pho|​S529_pho|​K218_ace|​K221_ace|​K310_ace:​NF-_kappa_ B_br_(p50))|​active@unknown
24. CBP:​NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk|​K218_ace|​K221_ace|​K310_ace:​NF-_kappa_ B_br_(p50):​_kappa_ B site@unknown → target genes_br_ex. IL-1, IL-8, IL-6, TNF_alpha_ , IFN_gamma_ , GM-CSF, M-CSF,_br_iNOS, COX2, MHC class I / II, E-selectin, _beta_ -defensin2@unknown
25. CBP:​NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk|​K218_ace|​K221_ace|​K310_ace:​NF-_kappa_ B_br_(p50):​_kappa_ B site@unknown → NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk|​K123_unk|​K218_unk|​K221_unk|​K310_unk@unknown + g_kappa_ B site@unknown + NF-_kappa_ B_br_(p50)@unknown + CBP@unknown
26. (NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_pho|​S536_pho|​S529_pho|​K218_ace|​K221_ace|​K310_ace:​NF-_kappa_ B_br_(p50))|​active@unknown → (NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_pho|​S536_pho|​S529_pho:​NF-_kappa_ B_br_(p50))|​active@unknown
27. (NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_pho|​S536_pho|​S529_pho|​K218_ace|​K221_ace|​K310_ace:​NF-_kappa_ B_br_(p50))|​active@unknown → NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_pho|​S536_pho|​S529_pho|​K123_ace|​K218_ace|​K221_ace|​K310_ace|​K122_ace:​NF-_kappa_ B_br_(p50)@unknown
28. NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_pho|​S536_pho|​S529_pho|​K123_ace|​K218_ace|​K221_ace|​K310_ace|​K122_ace:​NF-_kappa_ B_br_(p50)@unknown → (NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_pho|​S536_pho|​S529_pho|​K218_ace|​K221_ace|​K310_ace:​NF-_kappa_ B_br_(p50))|​active@unknown
29. CBP:​NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk|​K218_ace|​K221_ace|​K310_ace:​NF-_kappa_ B_br_(p50):​_kappa_ B site@unknown → NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_pho|​S536_pho|​S529_pho|​K123_ace|​K218_ace|​K221_ace|​K310_ace|​K122_ace:​NF-_kappa_ B_br_(p50)@unknown + g_kappa_ B site@unknown + CBP@unknown
30. (NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_pho|​S536_pho|​S529_pho|​K218_ace|​K221_ace|​K310_ace:​NF-_kappa_ B_br_(p50))|​active@unknown + CBP@unknown + g_kappa_ B site@unknown → CBP:​NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk|​K218_ace|​K221_ace|​K310_ace:​NF-_kappa_ B_br_(p50):​_kappa_ B site@unknown
31. CBP:​NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk|​K218_ace|​K221_ace|​K310_ace:​NF-_kappa_ B_br_(p50):​_kappa_ B site@unknown → gIL-1_alpha@unknown
32. CBP:​NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk|​K218_ace|​K221_ace|​K310_ace:​NF-_kappa_ B_br_(p50):​_kappa_ B site@unknown → gIL-1_beta@unknown
33. CBP:​NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk|​K218_ace|​K221_ace|​K310_ace:​NF-_kappa_ B_br_(p50):​_kappa_ B site@unknown → gIL-1ra@unknown
34. NF-_kappa_ B_br_ (p65)|​S276_unk:​NF-_kappa_ B_br_(p50):​PKAc@cytosol → NF-_kappa_ B_br_ (p65)|​S276_pho:​NF-_kappa_ B_br_(p50)@cytosol + PKAc@cytosol

As Catalyser:

1. CBP:​NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_unk|​S536_unk|​S529_unk|​K218_ace|​K221_ace|​K310_ace:​NF-_kappa_ B_br_(p50):​_kappa_ B site@unknown → NF-_kappa_ B_br_ (p65)|​S276_pho|​S311_pho|​S536_pho|​S529_pho|​K123_ace|​K218_ace|​K221_ace|​K310_ace|​K122_ace:​NF-_kappa_ B_br_(p50)@unknown + g_kappa_ B site@unknown + CBP@unknown
2. gA20@unknown → rA20@unknown
3. gNF-_kappa_ B1@unknown → rNF-_kappa_ B1@cytosol
4. gI_kappa_ B_alpha@unknown → rI_kappa_ B_alpha@unknown
5. gelk-1@unknown → Elk-1@unknown
6. NF-_kappa_ B_br_ (p65)|​S276_unk:​NF-_kappa_ B_br_(p50):​PKAc@cytosol → NF-_kappa_ B_br_ (p65)|​S276_pho:​NF-_kappa_ B_br_(p50)@cytosol + PKAc@cytosol