External Collection

  • Access to: ReconMap 2
  • The Human metabolic reconstruction resource contains the most recent version of Recon2, a high-quality consensus reconstruction of human metabolism, assembled by the systems biology community.

    Recon 2 is a consensus metabolic reconstruction integrating metabolic information from five different resources.

    It is fully semantically annotated (Le Novère, N. et al. Nat Biotechnol 23, 1509-1515, 2005) with references to persistent and publicly available chemical and gene databases, unambiguously identifying its components and increasing its applicability for third-party users.

    ReconMap 2 is composed of 99 subsystems representing each a metabolic function. A GMT file containing a list of proteins implicated in those subsystems can be downloaded here. This file can be used to perform data visualisation in NaviCell based on subsystems and to perform Enrichment Analyses.

    This map is linked to the Atlas of Cancer Signalling Network (ACSN) through 252 common entities. A list of these entities can be downloaded here. Similarly, a GMT file containing genes lists (HUGO names) for corresponding ACSN map modules can be downloaded here.

    Crosstalks have been identified between ReconMap 2 subsystems and ACSN modules and can be visualised in the form of a network. A file containing this network's information can be downloaded at this link.

    The original ReconMap 2 map can be found on the VMH page

    Thiele et al. A community-driven global reconstruction of human metabolism. Nat Biotechnol. 2013 May;31(5):419-25. PMID:23455439