External Collection

  • Access to: mTOR signalling network
  • The mammalian target of rapamycin (mTOR) is a central regulator of cell growth and proliferation. mTOR signaling is frequently dysregulated in oncogenic cells, and thus an attractive target for anticancer therapy. mTOR map depicts our current understanding of the mTOR signaling and demonstrates impact of mTOR feedback and crosstalk regulations on drug-based cancer therapy.

    The map of mTOR signaling network includes 964 species connected by 777 reactions.

    Caron E., Ghosh S., Matsuoka Y., Ashton-Beaucage D., Therrien M., Lemieux S., Perreault C., Roux PP. A comprehensive map of the mTOR signaling network. Mol Syst Biol 2010 6: 453. PMID