Ion Ca2+ map
Ca2+@Endoplasmic Reticulum

References
 MACROPHAGE  map
 NATURAL_KILLER  map
CASCADE:IL13
CASCADE:SLAMF7
CASCADE:NKP80
CASCADE:NKG2D
CASCADE:KIR2DS4
CASCADE:Fc_gamma_RIII
CASCADE:CR1
PMID:16204312
Calcium influx is an early event during perforin-mediated cytotoxicity.
PMID:12740575, PMID:15972651
NKG2D signaling inducese PLCG2 phosphorylation and Ca2+ release.  The calcium signal generated by PLCG is required for NKG2D-initiated killing.
Calcium influx is an early event during perforin-mediated cytotoxicity. PLC-γ2 is absolutely required to regulate degranulation of cytotoxic perforin granules.
PMID:22683124
PLCG2-deficient NK cells displayed a partial reduction of conjugate formationwith target tumor cells probably via regulation of Ca2+ fluxes,
because a chelator of intracellular Ca2+ also provokes a partial reduction of conjugate formation.
PMID:11265639
Cross-linking of NKp80 induces Ca 2+ mobilization and
triggering of cytotoxicity in both resting and activated NK cells.
PMID:2536067, PMID:1281218
Ligation of Fc gamma RIII alpha (CD16)  induces the tyrosine phosphorylation of both phospholipase C (PLC)-gamma 1 and PLC-gamma 2 in natural killer cells and stimulates expression of many cytokines via Ca('2+) -depend mechanism.
PMID:7890616, PMID:10925299
PCL (probably PCLG1) induces hydrolysis of phosphoinositides and activates InsP3-induced intracellular Ca2+ release downstream of IL13. Intracellular Ca2+ release release induces cAMP Accumulation in Human monocytes and activation of PKA signaling downstream of IL13.

Ca2+@INNATE_IMMUNE_CELL_Cytosol

References
CASCADE:Fc_gamma_RIII
 NATURAL_KILLER  map
PMID:16204312
Calcium influx is an early event during perforin-mediated cytotoxicity.
PMID:12740575, PMID:15972651
NKG2D signaling inducese PLCG2 phosphorylation and Ca2+ release.  The calcium signal generated by PLCG is required for NKG2D-initiated killing.
Calcium influx is an early event during perforin-mediated cytotoxicity. PLC-γ2 is absolutely required to regulate degranulation of cytotoxic perforin granules.
PMID:22683124
PLCG2-deficient NK cells displayed a partial reduction of conjugate formationwith target tumor cells probably via regulation of Ca2+ fluxes,
because a chelator of intracellular Ca2+ also provokes a partial reduction of conjugate formation.
PMID:10089876, PMID:7650486, PMID:9973469
 Ca('2+) activates Calmodulin 2 ( Calmodulin )/ Protein phosphatase 3 (Calcineurin ) signal. Activated Calcineurin dephosphorylates Nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 2 ( NF-AT1(NFATC2) ). 
(PMID10089876). This signaling is activated downstream of CD16

Modifications:
In compartment: Endoplasmic Reticulum
  1. Ca2+@Endoplasmic Reticulum map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. Ca2+@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. Ca2+:​Calmodulin*@INNATE_IMMUNE_CELL_Cytosol map
  2. CNA*:​CNB*:​Ca2+:​Calmodulin*@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. Ca2+@INNATE_IMMUNE_CELL_Cytosol map → map EXOCYTOSIS_AND_PHAGOCYTOSIS@INNATE_IMMUNE_CELL_Membrane map
  2. Ca2+@Endoplasmic Reticulum map → map Ca2+@INNATE_IMMUNE_CELL_Cytosol map
  3. Ca2+@INNATE_IMMUNE_CELL_Cytosol map → map Conjugate_formation@INNATE_IMMUNE_CELL_Membrane map
  4. Ca2+@INNATE_IMMUNE_CELL_Cytosol map + Calmodulin*@INNATE_IMMUNE_CELL_Cytosol map → map Ca2+:​Calmodulin*@INNATE_IMMUNE_CELL_Cytosol map
  5. Ca2+:​Calmodulin*@INNATE_IMMUNE_CELL_Cytosol map + CNA*:​CNB*@INNATE_IMMUNE_CELL_Cytosol map → map CNA*:​CNB*:​Ca2+:​Calmodulin*@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. Tumor_antigen@TUMOR_CELL_AS_EFFECTOR map → map Tumor_antigen@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
  2. ATP@INNATE_IMMUNE_CELL_Cytosol map → map cAMP@INNATE_IMMUNE_CELL_Cytosol map
  3. NFAT*|​pho@INNATE_IMMUNE_CELL_Cytosol map → map NFAT*@INNATE_IMMUNE_CELL_Cytosol map
  4. Actin cytoskeletal*@INNATE_IMMUNE_CELL_Cytosol map → map Actin cytoskeletal*|​hm2|​active@INNATE_IMMUNE_CELL_Cytosol map
  5. gNFAT*@INNATE_IMMUNE_CELL_Cytosol map → map rNFAT*@INNATE_IMMUNE_CELL_Cytosol map