Protein KIR2DL2 map

Identifiers
HUGO::KIR2DL2

Maps_Modules
MODULE:INPUT_INHIBITORS MODULE:INHIBITION_OF_TUMOR_RECOGNITION MODULE:NK_INHIBITING_RECEPTORS

References
CASCADE:KIR2DL2
 NATURAL_KILLER  map
PMID:11513144
KIRs constitute a family of slightly polymorphic receptors with distinct MHC-I-binding profiles for classical HLA-A, HLA-B, and HLA-C molecules. Most KIRs with two Ig domains (KIR2DL) recognize subsets of the HLA-C allotypes.
PMID:21339333
KIR2DL2 signaling blocks the initiation of activating responses downstream of HLA-C via SHP-1,SHP-2.
KIR2DL2 signaling inhibits IFNG secretion and Ca2+ mobilization, probably via inhibition of NKG2D-DAP10 signaling.
PMID:9605119
Interactions of KIR2DL2 or KIR2DL3 (KIR2DL2/3) with HLA-Cw3-related allotypes on melanomas resulted in decreased tumor cell lysis.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. KIR2DL2@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. HLA-C:​KIR2DL2@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. HLA-C@TUMOR_CELL_AS_INDUCTOR_Membrane map + KIR2DL2@INNATE_IMMUNE_CELL_Membrane map → map HLA-C:​KIR2DL2@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. IFNG@INNATE_IMMUNE_CELL_Cytosol map → map IFNG@default map
  2. GRB2@INNATE_IMMUNE_CELL_Cytosol map + DAP10:​NKG2D*@INNATE_IMMUNE_CELL_Membrane map → map DAP10|​pho:​GRB2:​NKG2D*@INNATE_IMMUNE_CELL_Membrane map
  3. PTPN6@INNATE_IMMUNE_CELL_Cytosol map → map PTPN6@INNATE_IMMUNE_CELL_Cytosol map
  4. PTPN11@INNATE_IMMUNE_CELL_Cytosol map → map PTPN11@INNATE_IMMUNE_CELL_Cytosol map