Protein IL2RA map

Identifiers
HUGO:IL2RA

Maps_Modules
MODULE:INPUT_ACTIVATORS MODULE:IMMUNE_STIMULATION MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS

References
 NATURAL_KILLER  map
 DENDRITIC_CELL  map
CASCADE:IL2
CASCADE:IL15
CASCADE:IL21
PMID:10849428
IL-2 and IL-15 are able to induce the phosphorylation of ERK1/2. probably via PI3K pathway.
MKK/ERK pathway is necessary for IL-2 to activate NK cells to express at least four known biological responses: LAK generation, IFN-gamma secretion, and IL2RA (CD25) and CLEC2C(CD69) expression.
PMID:10820393, PMID:24829413
IL2 receptor is expressed in dendritic cells. The IL-2R is composed of three different subunits,
IL-2R alpha (CD25), IL-2/15R beta (CD122) and gamma (CD131)

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. IL2RA@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. IL2RA:​IL2RB:​IL2RG@INNATE_IMMUNE_CELL_Membrane map
  2. IL2:​IL2RA:​IL2RB:​IL2RG:​JAK1:​JAK3@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. IL2RG@INNATE_IMMUNE_CELL_Membrane map + IL2RA@INNATE_IMMUNE_CELL_Cytosol map + IL2RB@INNATE_IMMUNE_CELL_Cytosol map → map IL2RA:​IL2RB:​IL2RG@INNATE_IMMUNE_CELL_Membrane map
  2. IL2@default map + IL2RA:​IL2RB:​IL2RG@INNATE_IMMUNE_CELL_Membrane map + JAK1@INNATE_IMMUNE_CELL_Cytosol map + JAK3@INNATE_IMMUNE_CELL_Cytosol map → map IL2:​IL2RA:​IL2RB:​IL2RG:​JAK1:​JAK3@INNATE_IMMUNE_CELL_Membrane map
  3. rIL2RA@INNATE_IMMUNE_CELL_Cytosol map → map IL2RA@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. STAT5*@INNATE_IMMUNE_CELL_Cytosol map → map STAT5*|​pho@INNATE_IMMUNE_CELL_Cytosol map