Protein JAK1 map

Identifiers
HUGO:JAK1

References
 MACROPHAGE  map
 DENDRITIC_CELL  map
MODULE:INPUT_INHIBITORS
MODULE:IMMUNE_SUPPRESSION
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
CASCADE:IL10
CASCADE:IL4
CASCADE:IL13
CASCADE:IL6
CASCADE:GSF3
MODULE:INPUT_ACTIVATORS
MODULE:IMMUNE_STIMULATION
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
 NATURAL_KILLER  map
CASCADE:IL15
CASCADE:IL21
CASCADE:IL2
CASCADE:IFNAB
‭21115385
‭JAK1 is a member of the Janus kinase family.
‭The binding of IL-10 to its receptor activates two members of the Janus kinase family: Jak1 (associated with the IL-1OR1 and
Tyk2 (associated with the IL-10R2)
PMID:19833085
IFNG receptor is assosiated with kinases JAK1 and JAK2
PMID:7512720, PMID:7521688
Jak1 and Jak2 are activated by the G-CSFR

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. JAK1@INNATE_IMMUNE_CELL_Cytosol map
  2. JAK1|​pho@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. IFNAR1:​IFNAR2:​JAK1:​TYK2@INNATE_IMMUNE_CELL_Membrane map
  2. CSF3R:​GSF3:​JAK1|​pho:​JAK2|​pho@INNATE_IMMUNE_CELL_Membrane map
  3. IL21:​IL21R:​IL2RG:​JAK1|​pho:​JAK3@INNATE_IMMUNE_CELL_Membrane map
  4. IFNGR1|​pho:​IFNGR2:​IFNG|​hm2:​JAK1:​JAK2@INNATE_IMMUNE_CELL_Membrane map
  5. IL10:​IL10RA|​Y446_pho|​Y496_pho:​IL10RB:​JAK1|​pho:​TYK2|​pho@INNATE_IMMUNE_CELL_Membrane map
  6. IL2:​IL2RA:​IL2RB:​IL2RG:​JAK1:​JAK3@INNATE_IMMUNE_CELL_Membrane map
  7. IL2RG:​IL4:​IL4R:​JAK1|​pho:​JAK2:​JAK3@INNATE_IMMUNE_CELL_Membrane map
  8. IL2RG:​IL4:​IL4R:​JAK1|​pho:​JAK2:​JAK3@INNATE_IMMUNE_CELL_Membrane map
  9. IL13RA1:​IL4:​IL4R:​JAK1|​pho:​JAK2:​TYK2@INNATE_IMMUNE_CELL_Membrane map
  10. IL13RA1:​IL4:​IL4R:​JAK1|​pho:​JAK2:​TYK2@INNATE_IMMUNE_CELL_Membrane map
  11. IL15:​IL15RA:​IL2RB|​pho:​IL2RG:​JAK1:​JAK3@INNATE_IMMUNE_CELL_Membrane map
  12. IL13:​IL13RA1|​pho:​IL4R|​pho:​JAK1:​JAK2|​pho:​TYK2|​pho@INNATE_IMMUNE_CELL_Membrane map
  13. IL13:​IL13RA1|​pho:​IL4R|​pho:​JAK1:​JAK2|​pho:​TYK2|​pho@INNATE_IMMUNE_CELL_Membrane map
  14. IL6:​IL6R:​JAK1|​pho:​JAK2|​pho:​TYK2|​pho:​gp130*|​Y759_pho@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. JAK1@INNATE_IMMUNE_CELL_Cytosol map → map JAK1|​pho@INNATE_IMMUNE_CELL_Cytosol map
  2. IL10:​IL10RA:​IL10RB@INNATE_IMMUNE_CELL_Membrane map + JAK1|​pho@INNATE_IMMUNE_CELL_Cytosol map + TYK2|​pho@INNATE_IMMUNE_CELL_Cytosol map → map IL10:​IL10RA|​Y446_pho|​Y496_pho:​IL10RB:​JAK1|​pho:​TYK2|​pho@INNATE_IMMUNE_CELL_Membrane map
  3. IL2RG:​IL4:​IL4R@INNATE_IMMUNE_CELL_Membrane map + JAK3@INNATE_IMMUNE_CELL_Cytosol map + JAK1|​pho@INNATE_IMMUNE_CELL_Cytosol map + JAK2|​pho@INNATE_IMMUNE_CELL_Cytosol map → map IL2RG:​IL4:​IL4R:​JAK1|​pho:​JAK2:​JAK3@INNATE_IMMUNE_CELL_Membrane map
  4. IL13RA1:​IL4:​IL4R@INNATE_IMMUNE_CELL_Membrane map + JAK1|​pho@INNATE_IMMUNE_CELL_Cytosol map + TYK2@INNATE_IMMUNE_CELL_Cytosol map + JAK2@INNATE_IMMUNE_CELL_Cytosol map → map IL13RA1:​IL4:​IL4R:​JAK1|​pho:​JAK2:​TYK2@INNATE_IMMUNE_CELL_Membrane map
  5. IL13:​IL13RA1:​IL4R@INNATE_IMMUNE_CELL_Membrane map + JAK2|​pho@INNATE_IMMUNE_CELL_Cytosol map + TYK2|​pho@INNATE_IMMUNE_CELL_Cytosol map + JAK1@INNATE_IMMUNE_CELL_Cytosol map → map IL13:​IL13RA1|​pho:​IL4R|​pho:​JAK1:​JAK2|​pho:​TYK2|​pho@INNATE_IMMUNE_CELL_Membrane map
  6. IL6:​IL6R:​gp130*|​Y759_pho@INNATE_IMMUNE_CELL_Membrane map + JAK1|​pho@INNATE_IMMUNE_CELL_Cytosol map + TYK2|​pho@INNATE_IMMUNE_CELL_Cytosol map + JAK2|​pho@INNATE_IMMUNE_CELL_Cytosol map → map IL6:​IL6R:​JAK1|​pho:​JAK2|​pho:​TYK2|​pho:​gp130*|​Y759_pho@INNATE_IMMUNE_CELL_Membrane map
  7. CSF3R:​GSF3@INNATE_IMMUNE_CELL_Membrane map + JAK1|​pho@INNATE_IMMUNE_CELL_Cytosol map + JAK2|​pho@INNATE_IMMUNE_CELL_Cytosol map → map CSF3R:​GSF3:​JAK1|​pho:​JAK2|​pho@INNATE_IMMUNE_CELL_Membrane map
  8. IFNG|​hm2@default map + IFNGR1:​IFNGR2@INNATE_IMMUNE_CELL_Membrane map + JAK1@INNATE_IMMUNE_CELL_Cytosol map + JAK2@INNATE_IMMUNE_CELL_Cytosol map → map IFNGR1|​pho:​IFNGR2:​IFNG|​hm2:​JAK1:​JAK2@INNATE_IMMUNE_CELL_Membrane map
  9. IFNAR1:​IFNAR2@INNATE_IMMUNE_CELL_Membrane map + JAK1@INNATE_IMMUNE_CELL_Cytosol map + TYK2@INNATE_IMMUNE_CELL_Cytosol map → map IFNAR1:​IFNAR2:​JAK1:​TYK2@INNATE_IMMUNE_CELL_Membrane map
  10. IL15RA:​IL2RB:​IL2RG@INNATE_IMMUNE_CELL_Membrane map + IL15@default map + JAK1@INNATE_IMMUNE_CELL_Cytosol map + JAK3@INNATE_IMMUNE_CELL_Cytosol map → map IL15:​IL15RA:​IL2RB|​pho:​IL2RG:​JAK1:​JAK3@INNATE_IMMUNE_CELL_Membrane map
  11. IL4@default map + IL2RG:​IL4R@INNATE_IMMUNE_CELL_Membrane map + JAK3@INNATE_IMMUNE_CELL_Cytosol map + JAK1@INNATE_IMMUNE_CELL_Cytosol map + JAK2@INNATE_IMMUNE_CELL_Cytosol map → map IL2RG:​IL4:​IL4R:​JAK1|​pho:​JAK2:​JAK3@INNATE_IMMUNE_CELL_Membrane map
  12. IL4@default map + IL13RA1:​IL4R@INNATE_IMMUNE_CELL_Membrane map + JAK1@INNATE_IMMUNE_CELL_Cytosol map + JAK2@INNATE_IMMUNE_CELL_Cytosol map + TYK2@INNATE_IMMUNE_CELL_Cytosol map → map IL13RA1:​IL4:​IL4R:​JAK1|​pho:​JAK2:​TYK2@INNATE_IMMUNE_CELL_Membrane map
  13. IL13@default map + IL13RA1:​IL4R@INNATE_IMMUNE_CELL_Membrane map + JAK2@INNATE_IMMUNE_CELL_Cytosol map + JAK1@INNATE_IMMUNE_CELL_Cytosol map + TYK2@INNATE_IMMUNE_CELL_Cytosol map → map IL13:​IL13RA1|​pho:​IL4R|​pho:​JAK1:​JAK2|​pho:​TYK2|​pho@INNATE_IMMUNE_CELL_Membrane map
  14. IL2@default map + IL2RA:​IL2RB:​IL2RG@INNATE_IMMUNE_CELL_Membrane map + JAK1@INNATE_IMMUNE_CELL_Cytosol map + JAK3@INNATE_IMMUNE_CELL_Cytosol map → map IL2:​IL2RA:​IL2RB:​IL2RG:​JAK1:​JAK3@INNATE_IMMUNE_CELL_Membrane map
  15. IL21@default map + IL21R:​IL2RG@INNATE_IMMUNE_CELL_Membrane map + JAK1@INNATE_IMMUNE_CELL_Cytosol map + JAK3@INNATE_IMMUNE_CELL_Cytosol map → map IL21:​IL21R:​IL2RG:​JAK1|​pho:​JAK3@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. TNF@INNATE_IMMUNE_CELL_Cytosol map → map TNF@default map
  2. gTIMP3@INNATE_IMMUNE_CELL_Cytosol map → map rTIMP3@INNATE_IMMUNE_CELL_Cytosol map
  3. PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol map → map PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol map
  4. STAT3@INNATE_IMMUNE_CELL_Cytosol map → map STAT3|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  5. CD83@INNATE_IMMUNE_CELL_Cytosol map → map CD83@INNATE_IMMUNE_CELL_Membrane map
  6. IRS2@INNATE_IMMUNE_CELL_Cytosol map → map IRS2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  7. STAT1@INNATE_IMMUNE_CELL_Cytosol map → map STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  8. STAT6@INNATE_IMMUNE_CELL_Cytosol map → map STAT6|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  9. gIL12p40*@INNATE_IMMUNE_CELL_Cytosol map → map rIL12p40*@INNATE_IMMUNE_CELL_Cytosol map
  10. gIL23A@INNATE_IMMUNE_CELL_Cytosol map → map rIL23A@INNATE_IMMUNE_CELL_Cytosol map
  11. gIL18@INNATE_IMMUNE_CELL_Cytosol map → map rIL18@INNATE_IMMUNE_CELL_Cytosol map
  12. gINHBA@INNATE_IMMUNE_CELL_Cytosol map → map rINHBA@INNATE_IMMUNE_CELL_Cytosol map
  13. STAT1@INNATE_IMMUNE_CELL_Cytosol map → map STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  14. gIL15@INNATE_IMMUNE_CELL_Cytosol map → map rIL15@INNATE_IMMUNE_CELL_Cytosol map
  15. gIL15RA@INNATE_IMMUNE_CELL_Cytosol map → map rIL15RA@INNATE_IMMUNE_CELL_Cytosol map
  16. STAT6@INNATE_IMMUNE_CELL_Cytosol map → map STAT6|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  17. gMICA@INNATE_IMMUNE_CELL_Cytosol map → map rMICA@INNATE_IMMUNE_CELL_Cytosol map
  18. gMICB@INNATE_IMMUNE_CELL_Cytosol map → map rMICB@INNATE_IMMUNE_CELL_Cytosol map
  19. STAT3@INNATE_IMMUNE_CELL_Cytosol map → map STAT3|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  20. STAT5*@INNATE_IMMUNE_CELL_Cytosol map → map STAT5*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  21. STAT4@INNATE_IMMUNE_CELL_Cytosol map → map STAT4|​pho@INNATE_IMMUNE_CELL_Cytosol map