Identifiers
HUGO:STAT5A HUGO:STAT5B

Maps_Modules
MODULE:INPUT_ACTIVATORS MODULE:IMMUNE_STIMULATION MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS

References
 MACROPHAGE 
 MDSC 
 NATURAL_KILLER 
CASCADE:IL15
CASCADE:IL21
CASCADE:IL2
CASCADE:CSF2
PMID:20406969, PMID:24091328, PMID:11867689
GM-CSF uniquely inhibited signal transducers and activators of transcription (STAT3) and promoted STAT5 activation, probably downstream of JAK2. STAT5ab(null/null) MDSC were rendered sensitive to sunitinib in the presence of GM-CSF in vitro.
PMID:24091328
G-CSF downregulates IRF8 expression via STAT3 and GM-CSF via STAT5. IRF8 inhibition provides immunosuppressive functions of MDSC.
PMID:20231889
Dcs Stat5-Tg mice are expressing ot surface high levels of MHC-II and costimulatory molecules such as CD80, CD86 and CD54 (ICAM1) and have increased level of I12 secretion (.)

1. STAT5*@INNATE_IMMUNE_CELL_Cytosol
2. STAT5*|​pho@INNATE_IMMUNE_CELL_Cytosol

1. STAT5*@INNATE_IMMUNE_CELL_Cytosol → STAT5*|​pho@INNATE_IMMUNE_CELL_Cytosol

1. ICAM1@INNATE_IMMUNE_CELL_Cytosol → ICAM1@INNATE_IMMUNE_CELL_Membrane
2. IL12*@INNATE_IMMUNE_CELL_Cytosol → IL12*@default
3. CD80@INNATE_IMMUNE_CELL_Cytosol → CD80@INNATE_IMMUNE_CELL_Membrane
4. CD86@INNATE_IMMUNE_CELL_Cytosol → CD86@INNATE_IMMUNE_CELL_Membrane
5. gCIITA@INNATE_IMMUNE_CELL_Cytosol → rCIITA@INNATE_IMMUNE_CELL_Cytosol
6. gMYD88@INNATE_IMMUNE_CELL_Cytosol → rMYD88@INNATE_IMMUNE_CELL_Cytosol
7. gIRF1@INNATE_IMMUNE_CELL_Cytosol → rIRF1@INNATE_IMMUNE_CELL_Cytosol
8. gIFNG@INNATE_IMMUNE_CELL_Cytosol → rIFNG@INNATE_IMMUNE_CELL_Cytosol
9. gIL2RA@INNATE_IMMUNE_CELL_Cytosol → rIL2RA@INNATE_IMMUNE_CELL_Cytosol
10. gIRF8@INNATE_IMMUNE_CELL_Cytosol → rIRF8@INNATE_IMMUNE_CELL_Cytosol
11. gPRF1@INNATE_IMMUNE_CELL_Cytosol → rPRF1@INNATE_IMMUNE_CELL_Cytosol