Protein IL2 map

Identifiers
HUGO:1L2

Maps_Modules
MODULE:INPUT_ACTIVATORS MODULE:IMMUNE_STIMULATION MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS MODULE:EFFECTOR_ACTIVATION MODULE:IMMUNOSTIMULATORY_CYTOKINE_EXPRESSION

References
 NATURAL_KILLER  map
CASCADE:Fc_gamma_RIII
CASCADE:IL15
CASCADE:CD40LG
CASCADE:NKp30
PMID:6164929
IL2 has the ability to augment the cytotoxic activity of natural killer (NK) cells agains tumor cells
and potentiate effect of other cytokines (interferons).
PMID:15289500
Dendric cells-derived IL-2 induces NK cell activation.
DC-derived IL-2 Is Required In Vitro to Elicit IFNγ Production from NK Cells.
PMID:23650441
IL-2–treated NK cells had a significantly increased contact efficiency as determined by the number of target cell contacts that cells underwent before initiating Ca2+ flux for the first time
The ability of IL-2 to modulate NK cell cytotoxicity directly correlated with its ability to increase target–cell conjugation.
IL-2 rapidly increases NK cell adhesion to and killing of weak targets.
NK cell reactivity toward missing-self targets was enhanced in the absence of T reg cells and depended on the availability of IL-2 and activated T cells.
CD4+ T cell–derived IL-2 activated NK cells in the absence of T reg cells.
PMID:19528259
Nkp30‭ ‬signaling induces IL2‭ ‬release.
PMID:9625766
IL2‭ ‬stimulates NKp44‭ ‬surface expression in NK cells.
PMID:10807786
Interleukin-2 enhances the response of natural killer cells to interleukin-12 through up-regulation of the interleukin-12 receptor and STAT4
PMID:15563472
Interleukins 2 and 15 regulate Ets1 expression via ERK1/2 and MNK1 in human natural killer cells.
 15353479
Human and mouse DCs produce IL-2 downstream of IL15+CD40L signaling

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. IL2@INNATE_IMMUNE_CELL_Cytosol map
In compartment: default
  1. IL2@default map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. IL2:​IL2RA:​IL2RB:​IL2RG:​JAK1:​JAK3@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. IL2@INNATE_IMMUNE_CELL_Cytosol map → map IMMUNE_ACTIVATION@default map
  2. rIL2@INNATE_IMMUNE_CELL_Cytosol map → map IL2@INNATE_IMMUNE_CELL_Cytosol map
  3. IL2@default map + IL2RA:​IL2RB:​IL2RG@INNATE_IMMUNE_CELL_Membrane map + JAK1@INNATE_IMMUNE_CELL_Cytosol map + JAK3@INNATE_IMMUNE_CELL_Cytosol map → map IL2:​IL2RA:​IL2RB:​IL2RG:​JAK1:​JAK3@INNATE_IMMUNE_CELL_Membrane map
  4. IL2@INNATE_IMMUNE_CELL_Cytosol map → map IL2@default map
As Catalyser:
  1. gTBX21@INNATE_IMMUNE_CELL_Cytosol map → map rTBX21@INNATE_IMMUNE_CELL_Cytosol map
  2. NKp44*@INNATE_IMMUNE_CELL_Cytosol map → map NKp44*@INNATE_IMMUNE_CELL_Membrane map
  3. WASF2@INNATE_IMMUNE_CELL_Cytosol map → map WASF2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  4. IL12RB2@INNATE_IMMUNE_CELL_Cytosol map → map IL12RB2@INNATE_IMMUNE_CELL_Cytosol map
  5. IL12RB1@INNATE_IMMUNE_CELL_Cytosol map → map IL12RB1@INNATE_IMMUNE_CELL_Cytosol map
  6. LTA@INNATE_IMMUNE_CELL_Cytosol map → map LTA@INNATE_IMMUNE_CELL_Cytosol map
  7. ERK1/2*@INNATE_IMMUNE_CELL_Cytosol map → map ERK1/2*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  8. gSH2D1A@INNATE_IMMUNE_CELL_Cytosol map → map rSH2D1A@INNATE_IMMUNE_CELL_Cytosol map
  9. NKp46*@INNATE_IMMUNE_CELL_Cytosol map → map NKp46*@INNATE_IMMUNE_CELL_Membrane map
  10. KIR2DL4@INNATE_IMMUNE_CELL_Cytosol map → map KIR2DL4@INNATE_IMMUNE_CELL_Membrane map
  11. STAT5*@INNATE_IMMUNE_CELL_Cytosol map → map STAT5*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  12. rSTAT4@INNATE_IMMUNE_CELL_Cytosol map → map STAT4@INNATE_IMMUNE_CELL_Cytosol map
  13. IKBKG:​IKK_alpha_*:​IKK_beta_*@INNATE_IMMUNE_CELL_Cytosol map → map IKBKG|​ubi:​IKK_beta_*|​pho:​MHC_class_I*@INNATE_IMMUNE_CELL_Cytosol map