Protein ARG1 map

Identifiers
HUGO:ARG1

Maps_Modules
 MACROPHAGE  map
 NEUTROPHIL  map
 MDSC  map
MODULE:TUMOR_KILLING
MODULE:EFFECTOR_ACTIVATION
MODULE:NO_ROS_PRODUCTION
CASCADE:LACTIC
CASCADE:TGFB
CASCADE:MIF

References
PMID:12193690, PMID:17476345
A hallmark of “alternative activation” (M2) of macrophages
is high arginase activity, which competes with inducible NO
synthase for L-arginine, the common substrate
of both enzymes. ARG1 activation has been regarded as one of
the most specific markers of M2 macrophages.
PMID:20644162
Human MDSC express AGR1
PMID:12496409
Arg1 is up-regulated in MDSC by IL-4.
Arg1 increases superoxide production in myeloid cells through a pathway that likely utilizes the reductase domain of inducible NO synthase (iNOS), and that superoxide is required for Arg1-dependent suppression of T cell function.
PMID:26819959
TANs (G-MDSC) produced much more ARG1 and ROS than autologous neutrophils and inhibited proliferation of activated autologous T cells and IFN-γ productionReferences_end

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. ARG1@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rARG1@INNATE_IMMUNE_CELL_Cytosol map → map ARG1@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. L-arginine@INNATE_IMMUNE_CELL_Cytosol map → map Urea@INNATE_IMMUNE_CELL_Cytosol map + L-ornitine@INNATE_IMMUNE_CELL_Cytosol map
    2. O_sub_2_endsub_@INNATE_IMMUNE_CELL_Cytosol map → map O_sub_2_endsub__super_-_endsuper_@INNATE_IMMUNE_CELL_Cytosol map