Identifiers
HUGO:VEGFA
Maps_Modules
MODULE:INPUT_INHIBITORS MODULE:IMMUNE_SUPPRESSION MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS MODULE:EFFECTOR_INHIBITION MODULE:TUMOR_GROWTH MODULE:ANGIOGENIC_FACTORS
References
DENDRITIC_CELL
MACROPHAGE
MDSC
MAST_CELL
CASCADE:VEGFA
CASCADE:LACTIC
CASCADE:MIF
CASCADE:IL4
CASCADE:TLR2_4
CASCADE:CSF2
CASCADE:IFNAB
NEUTROPHIL
PMID:15573129, PMID:8837607
Vascular endothelial growth factor (VEGF) was the first tumour-derived factor shown to inhibit DC differentiation.
The involvement of VEGF in tumour-induced defects in DC differentiation was indicated by in vitro experiments in which neutralizing VEGF-specific antibody abrogated the negative effect of tumour-cell-conditioned medium on the differentiation of DCs from HPCs.
(VEGF) inhibit the activation of NF-B by blocking IB phosphorylation55, 101, 102, possibly through activation of STAT3 (signal transducer and activator of transcription 3). Recent data have shown that STAT3 might also bind p65 subunits of NF-B, thereby directly inhibiting NF-B activity
PMID:9570538
VEGF inhibits TNF-α inducible activation of NF-κB in HPC, resulting in inhibition of DC differentiation
The presence of VEGF significantly decreased the specific DNA binding of NF-kappa B as early as 30 min after induction with TNF-alpha. This was followed on days 7 to 10 by decreases in the mRNA for RelB and c-Rel, two subunits of NF-kappa B.
PMID:16002046
Vascular endothelial growth factor impairs the functional ability of dendritic cells through Id pathways.
PMID:17086423
Vascular endothelial growth factor inhibits the function of
human mature dendritic cells mediated by VEGF receptor-2 (KDR)
PMID:23390297, PMID:22461508
MIF signaling induces angiogenesis probavly via upregulation of MMP9, VEGF expression in macrophages and activates tumor invasion
PMID:21372296
HMGB1 induces the production of angiogenic factors VEGF, and TGFB1 by macrophage via TLR4-dependent mechanisms.
PMID:15099563
Mast cells produce heparin, interleukin-8 (IL-8) and vascular
endothelial cell growth factor (VEGF), which induce
neovascularization,
PMID:15520864
MC-derived Ang-1 and VEGF-A promotes
growth of plasmocytomas by stimulating neovascularization.