Protein VEGFA map

Identifiers
HUGO:VEGFA

Maps_Modules
MODULE:INPUT_INHIBITORS MODULE:IMMUNE_SUPPRESSION MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS MODULE:EFFECTOR_INHIBITION MODULE:TUMOR_GROWTH MODULE:ANGIOGENIC_FACTORS

References
 DENDRITIC_CELL  map
 MACROPHAGE  map
 MDSC  map
 MAST_CELL  map
CASCADE:VEGFA
CASCADE:LACTIC
CASCADE:MIF
CASCADE:IL4
CASCADE:TLR2_4
CASCADE:CSF2
CASCADE:IFNAB
 NEUTROPHIL  map
PMID:15573129, PMID:8837607
Vascular endothelial growth factor (VEGF) was the first tumour-derived factor shown to inhibit DC differentiation.
The involvement of VEGF in tumour-induced defects in DC differentiation was indicated by in vitro experiments in which neutralizing VEGF-specific antibody abrogated the negative effect of tumour-cell-conditioned medium on the differentiation of DCs from HPCs.
(VEGF) inhibit the activation of NF-B by blocking IB phosphorylation55, 101, 102, possibly through activation of STAT3 (signal transducer and activator of transcription 3). Recent data have shown that STAT3 might also bind p65 subunits of NF-B, thereby directly inhibiting NF-B activity
PMID:9570538
VEGF inhibits TNF-α inducible activation of NF-κB in HPC, resulting in inhibition of DC differentiation
The presence of VEGF significantly decreased the specific DNA binding of NF-kappa B as early as 30 min after induction with TNF-alpha. This was followed on days 7 to 10 by decreases in the mRNA for RelB and c-Rel, two subunits of NF-kappa B.
PMID:16002046
Vascular endothelial growth factor impairs the functional ability of dendritic cells through Id pathways.
PMID:17086423
Vascular endothelial growth factor inhibits the function of
human mature dendritic cells mediated by VEGF receptor-2 (KDR)
PMID:23390297, PMID:22461508
MIF signaling induces angiogenesis probavly via upregulation of MMP9, VEGF expression in macrophages and activates tumor invasion
PMID:21372296
HMGB1 induces the production of angiogenic factors VEGF, and TGFB1 by macrophage via TLR4-dependent mechanisms.
PMID:15099563
Mast cells produce heparin, interleukin-8 (IL-8) and vascular
endothelial cell growth factor (VEGF), which induce
neovascularization,
PMID:15520864
MC-derived Ang-1 and VEGF-A promotes
growth of plasmocytomas by stimulating neovascularization.


Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. VEGFA@INNATE_IMMUNE_CELL_Cytosol map
In compartment: default
  1. VEGFA@default map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. KDR:​VEGFA@INNATE_IMMUNE_CELL_Membrane map
  2. FLT1:​VEGFA@INNATE_IMMUNE_CELL_Membrane map
In compartment: default
  1. VEGFA:​trVEGFR1*@default map
Participates in reactions:
As Reactant or Product:
  1. KDR@INNATE_IMMUNE_CELL_Membrane map + VEGFA@default map map KDR:​VEGFA@INNATE_IMMUNE_CELL_Membrane map
  2. VEGFA@default map + FLT1@INNATE_IMMUNE_CELL_Membrane map map FLT1:​VEGFA@INNATE_IMMUNE_CELL_Membrane map
  3. VEGFA@INNATE_IMMUNE_CELL_Cytosol map map VEGFA@default map
  4. trVEGFR1*@default map + VEGFA@default map map VEGFA:​trVEGFR1*@default map
  5. VEGFA:​trVEGFR1*@default map map degraded
  6. VEGFA@default map map ANGIOGENESIS@default map
  7. VEGFA@INNATE_IMMUNE_CELL_Cytosol map map VEGFA@default map
  8. rVEGFA@INNATE_IMMUNE_CELL_Cytosol map map VEGFA@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. gcREL*@INNATE_IMMUNE_CELL_Cytosol map map rcREL*@INNATE_IMMUNE_CELL_Cytosol map
  2. gRELB@INNATE_IMMUNE_CELL_Cytosol map map rRELB@INNATE_IMMUNE_CELL_Cytosol map
  3. ID1@INNATE_IMMUNE_CELL_Cytosol map map ID1@INNATE_IMMUNE_CELL_Cytosol map
  4. ERK1/2*@INNATE_IMMUNE_CELL_Cytosol map map ERK1/2*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  5. IKBKG:​IKK_alpha_*:​IKK_beta_*@INNATE_IMMUNE_CELL_Cytosol map map IKBKG|​ubi:​IKK_beta_*|​pho:​MHC_class_I*@INNATE_IMMUNE_CELL_Cytosol map