Identifiers
HUGO:RAC1 HUGO:RAC2
Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS MODULE:IMMUNE_STIMULATION MODULE:ANTIGEN_PRESENTATION MODULE:EFFECTOR_ACTIVATION MODULE:TUMOR_KILLING MODULE:NO_ROS_PRODUCTION
References
DENDRITIC_CELL
NATURAL_KILLER
CASCADE:NKP46
CASCADE:INTEGRIN_A4B1
CASCADE:INTEGRIN_A5B1
CASCADE:INTEGRIN_AVB5
PMID:11062502, PMID:11385609, PMID:11907067, PMID:15536084
Nkp46 controls NK cytolitic activity via PI3K /RAC1/PAK1/MEK /ERK pathway, probably throught SYK
PMID:19372727
The enzyme responsible for O2•- production is called the NADPH oxidase or respiratory burst oxidase. This multicomponent enzyme system is composed of two transmembrane proteins (p22phox and gp91phox, also called NOX2, which together form the cytochrome b558) and four cytosolic proteins (p47phox, p67phox, p40phox and a GTPase Rac1 or Rac2), which assemble at membrane sites upon cell activation.
PMID:15169870
Cdc42 activation was restricted to the leading margin of the cell, whereas Rac1 was active throughout the phagocytic cup. During phagosome closure, activation of Rac1 and Rac2 increased uniformly and transiently in the actin-poor region of phagosomal membrane. These distinct roles for Cdc42, Rac1, and Rac2 in the component activities of phagocytosis indicate mechanisms by which their differential regulation coordinates rearrangements of actin and membranes.
PMID:12740575
VAV1 activates RHOA and RAC1 downstream of NKG2D.
PMID:10679059, PMID:12626562
PTK2B, PYK2. Binding of NK cells to sensitive target cells or ligation of β2 integrins results in a rapid induction of Pyk2 phosphorylation and activation.
y contrast, no detectable Pyk2 tyrosine phosphorylation is found upon CD16 stimulation.
Pyk2 activation is a crucial event for natural but not Ab-dependent cytotoxicity.
Ligation of Beta2 integrins on NK cells resulted in Pyk2-dependent Erk activation, provavli via VAV1/RAC1 pathway.
Pyk-2-mediated control of integrin-triggered Rac-1 activation involves the regulation of Vav tyrosine phosphorylation.
PMID:14697347, PMID: 11146654
Integrin αvβ5 regulates phagocytosis via CRK /DOCK1 (DOCK180) /RAC1 pathway downstream of.
Integrin αvβ5 activation results in recruitment of the p130cas–CrkII–Dock180 complex and RAC1 activation.
+ GTP@INNATE_IMMUNE_CELL_Cytosol → (GTP:RAC1_2*)|active@INNATE_IMMUNE_CELL_Cytosol + GDP@INNATE_IMMUNE_CELL_Cytosol
+ NCF2@INNATE_IMMUNE_CELL_Cytosol + NCF4@INNATE_IMMUNE_CELL_Cytosol + CYBA@INNATE_IMMUNE_CELL_Cytosol + NCF1@INNATE_IMMUNE_CELL_Cytosol + CYBB@INNATE_IMMUNE_CELL_Cytosol + FAD@INNATE_IMMUNE_CELL_Cytosol + heme@INNATE_IMMUNE_CELL_Cytosol → CYBA:CYBB:FAD:GTP:NCF1:NCF2:NCF4:RAC1_2*:heme@INNATE_IMMUNE_CELL_Cytosol
→ EXOCYTOSIS_AND_PHAGOCYTOSIS@INNATE_IMMUNE_CELL_Membrane