Protein KLF4 map

Identifiers
HUGO:KLF4

Maps_Modules
 MACROPHAGE  map
MODULE:CORE_SIGNALING_PATHWAYS
MODULE:MIRNA_TF_IMMUNOSUPPRESSIVE
CASCADE:IL4

References
PMID:21670502
KLF4 together with STAT6 upregulates expression of PPARG and ARG1 downstream of IL4.
KLF4-deficient macrophages demonstrated increased proinflammatory gene expression, enhanced bactericidal activity, and altered metabolism.
KLF4 inhibits PTGS2 (COX2) expression. Probably via prevention of NFkB activaiton.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. KLF4@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rKLF4@INNATE_IMMUNE_CELL_Cytosol map → map KLF4@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. gPPARG@INNATE_IMMUNE_CELL_Cytosol map → map rPPARG@INNATE_IMMUNE_CELL_Cytosol map
    2. gARG1@INNATE_IMMUNE_CELL_Cytosol map → map rARG1@INNATE_IMMUNE_CELL_Cytosol map
    3. gPTGS2@INNATE_IMMUNE_CELL_Cytosol map → map rPTGS2@INNATE_IMMUNE_CELL_Cytosol map