Complex IL21:IL21R:IL2RG:JAK1:JAK3 map
Complex composition:

  1. IL21R map
  2. JAK1 map
  3. JAK3 map
  4. IL2RG map
  5. IL21 map

IL21:​IL21R:​IL2RG:​JAK1|​pho:​JAK3@INNATE_IMMUNE_CELL_Membrane

Identifiers
NAME:IL21:IL21R:IL2RG:JAK1:JAK3

Maps_Modules
MODULE:INPUT_ACTIVATORS MODULE:IMMUNE_STIMULATION MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS

References
 NATURAL_KILLER  map
CASCADE:IL21
PMID:24751819
Interleukin-21 (IL-21) is produced by CD4+ T cell populations, with the highest production by T follicular helper (TFH) cells and TH17 cells, and slightly lower levels produced by natural killer T (NKT) cells.
IL-21 signals via heterodimers of the IL-21 receptor (IL-21R) and the common cytokine receptor γ-chain, (encoded by IL2RG)

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. IL21:​IL21R:​IL2RG:​JAK1|​pho:​JAK3@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. IL21@default map + IL21R:​IL2RG@INNATE_IMMUNE_CELL_Membrane map + JAK1@INNATE_IMMUNE_CELL_Cytosol map + JAK3@INNATE_IMMUNE_CELL_Cytosol map → map IL21:​IL21R:​IL2RG:​JAK1|​pho:​JAK3@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol map → map PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol map
  2. STAT1@INNATE_IMMUNE_CELL_Cytosol map → map STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  3. STAT3@INNATE_IMMUNE_CELL_Cytosol map → map STAT3|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  4. STAT5*@INNATE_IMMUNE_CELL_Cytosol map → map STAT5*|​pho@INNATE_IMMUNE_CELL_Cytosol map