Protein TBK1 map

Maps_Modules
MODULE:INPUT_ACTIVATORS MODULE:TUMOR_RECOGNTITON MODULE:DANGER_SIGNAL_PATHWAYS MODULE:CORE_SIGNALING_PATHWAYS MODULE:MIRNA_TF_IMMUNOSTIMULATORY

References
 DENDRITIC_CELL  map
CASCADE:STING
PMID:25517615, PMID:25517609, PMID:24766893
Activated STING then recruits TBK1 to phosphorylate IRF3
PMID:23422957
IKKa could regulate IRF3 activity and IRF3-dependent IFNβ and IL-12 production by DC. TAK1 (MAP3K7)-mediated IKKα/β activation is required for IRF3-dependent IFNβ expression in DC. At the same time IKKα regulates IRF3-mediated transcription downstream of IKKɛ/TBK1mediated IRF3 phosphorylation. IKKa increases the association of IRF3 with the transcriptional co-activator CBP. The increased recruitment of CBP after overexpression of IKKα was also associated with increased transcription of endogenous IFNβ mRNA.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. TBK1@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. STING*:​TBK1:​cGAMP@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. TBK1@INNATE_IMMUNE_CELL_Cytosol map → map TBK1@INNATE_IMMUNE_CELL_Cytosol map
  2. STING*:​cGAMP@INNATE_IMMUNE_CELL_Cytosol map + TBK1@INNATE_IMMUNE_CELL_Cytosol map → map STING*:​TBK1:​cGAMP@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. IRF3@INNATE_IMMUNE_CELL_Cytosol map → map IRF3|​pho@INNATE_IMMUNE_CELL_Cytosol map