Complex STING*:TBK1:cGAMP map
Complex composition:

  1. cGAMP map
  2. STING* map
  3. TBK1 map

STING*:​TBK1:​cGAMP@INNATE_IMMUNE_CELL_Cytosol

Identifiers
NAME:STING*:TBK1:cGAMP

Maps_Modules
MODULE:INPUT_ACTIVATORS MODULE:TUMOR_RECOGNTITON MODULE:DANGER_SIGNAL_PATHWAYS

References
 DENDRITIC_CELL  map
CASCADE:STING
PMID:24766893
Cytosolic DNA induces type I IFNs through the endoplasmic reticulum membrane protein STING, which subsequently activates the transcription factors NF-κB and IRF3 through the kinases IKK and TBK1, respectively.
As a high-affinity ligand for STING, 2′3′-cGAMP binds and activates STING through a series of structural changes. Activated STING then recruits TBK1 to phosphorylate IRF3 and activate IKK to phosphorylate IκBα, leading to IκBα degradation.

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. STING*:​TBK1:​cGAMP@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. STING*:​cGAMP@INNATE_IMMUNE_CELL_Cytosol map + TBK1@INNATE_IMMUNE_CELL_Cytosol map → map STING*:​TBK1:​cGAMP@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. IRF3@INNATE_IMMUNE_CELL_Cytosol map → map IRF3|​pho@INNATE_IMMUNE_CELL_Cytosol map