Complex STING*:cGAMP map
Complex composition:

  1. STING* map
  2. cGAMP map

STING*:​cGAMP@INNATE_IMMUNE_CELL_Cytosol

Identifiers
NAME:STING*:cGAMP

Maps_Modules
MODULE:INPUT_ACTIVATORS MODULE:TUMOR_RECOGNTITON MODULE:DANGER_SIGNAL_PATHWAYS

References
 DENDRITIC_CELL  map
CASCADE:STING
PMID:24766893
Cytosolic DNA induces type I IFNs through the endoplasmic reticulum membrane protein STING, which subsequently activates the transcription factors NF-κB and IRF3 through the kinases IKK and TBK1, respectively

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. STING*:​cGAMP@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. STING*@INNATE_IMMUNE_CELL_Cytosol map + cGAMP@INNATE_IMMUNE_CELL_Cytosol map → map STING*:​cGAMP@INNATE_IMMUNE_CELL_Cytosol map
  2. STING*:​cGAMP@INNATE_IMMUNE_CELL_Cytosol map + TBK1@INNATE_IMMUNE_CELL_Cytosol map → map STING*:​TBK1:​cGAMP@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. IKBKG:​IKK_alpha_*:​IKK_beta_*@INNATE_IMMUNE_CELL_Cytosol map → map IKBKG|​ubi:​IKK_beta_*|​pho:​MHC_class_I*@INNATE_IMMUNE_CELL_Cytosol map