Protein IRF5 map

Identifiers
HUGO:IRF5

Maps_Modules
 MACROPHAGE  map
MODULE:CORE_SIGNALING_PATHWAYS
MODULE:MIRNA_TF_IMMUNOSTIMULATORY
CASCADE:MIF
CASCADE:CSF2

References
PMID:23390297
MIF inhitits expression of M1 markers such as IRF5
PMID:21240265
High expression of IRF5 was characteristic of M1 macrophages, in which it directly activated transcription of the genes encoding interleukin 12 subunit p40 (IL-12p40), IL-12p35 and IL-23p19 and repressed the gene encoding IL-10.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. IRF5@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rIRF5@INNATE_IMMUNE_CELL_Cytosol map → map IRF5@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. gIL10@INNATE_IMMUNE_CELL_Cytosol map → map rIL10@INNATE_IMMUNE_CELL_Cytosol map
    2. gIL12p40*@INNATE_IMMUNE_CELL_Cytosol map → map rIL12p40*@INNATE_IMMUNE_CELL_Cytosol map
    3. gIL12p35*@INNATE_IMMUNE_CELL_Cytosol map → map rIL12p35*@INNATE_IMMUNE_CELL_Cytosol map
    4. gIL23A@INNATE_IMMUNE_CELL_Cytosol map → map rIL23A@INNATE_IMMUNE_CELL_Cytosol map