RELB

Protein RELB

Identifiers
HUGO:RELB

Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS

References
DENDRITIC_CELL
CASCADE:VEGFA
PMID:9881974
RelB is essential for the development of myeloid-related CD8alpha- dendritic cells but not of lymphoid-related CD8alpha+ dendritic cells.
PMID:2308644
RelB promoted DC activation not as the expected RelB-p52 effector of the noncanonical NF-κB pathway, but as a RelB-p50 dimer regulated by canonical IκBs, IκBα and IκBɛ.
After stimulation with the TLR9 ligand CpG or the TLR2 ligand Pam3CSK4 for 24 h, we indeed observed reduced surface expression of DC activation markers MHCII, CD86, CD80 and CD40 in Relb−/− DCs (Fig. 5a and Supplementary Fig. 5a,b). Expression of proinflammatory genes, Tnf and Il23a, correlated with the kinetics of CpG or Pam3CSK4-induced RelB activation and were reduced in Relb−/− DCs (Fig. 5b). In EMSAs, activated RelB-p50 bound to DNA probes containing the κB sites found in the Tnf and Il23a promoters
Relb transcripts were reduced by ~40% in Rel−/− relative to wild-type BMDC
PMID:23086447
Alternative NFkB pathway induces via phosphorylation of IκB-specific kinase α (IKK-α) the cleavage of p100-RelB to p52-RelB, which then translocates as heterodimer into the nucleus.
Both complete p100 degradation and p100 processing to p52 may occur in Dcs and expression of IKKa, the kinase determining the activity of noncanonical NF-κB pathway, gradually increased during DC differentiation with concomitant p100 processing to p52
PMID:2649237
In macrophages RELB /p52 pathway is associated with M1 polarization ()

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol

RELB@INNATE_IMMUNE_CELL_Cytosol

Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol

Participates in reactions:
As Reactant or Product:

As Catalyser: