NFkB*

Protein NFkB*

Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS

References
MDSC
NEUTROPHIL
MACROPHAGE
CASCADE:IL2
CASCADE:IL18
CASCADE:CSF2
CASCADE:FT3LG
CASCADE:IFNG
CASCADE:IL1
PMID:10477595
FLT3 induced a high level of NF-κB nuclear translocation and specific DNA binding
VEGF inhibited FT3L-inducible activation of transcription factor NF-κB
PMID:12133954
IL-2R signals can activate a pathway leading to NF-κB p50/p65 activation in NK cells, IL2R signaling induces IkBa degradation and formation of heterodimeric p50/p65 NFkB complexes, NF-κB binds to the upstream enhancer of the perforin gene and that this pathway is involved in the activation of perforin expression (
PMID:20876105, PMID:17027520,
IL18 induces expression of NFKBIZ in NK cells provavly via NFkB pathway or via increasing of mRNA stability..).
PMID:17404308
CSF2 upregulates expression of TNF, and have positive influence on IL12p70 (p40+p35), IL23 (p40+p19) expression, probably via induction rapid IkBa degradation, RELA nuclear translocation and formation p65/p50 heterodimers provided induction of NFkB signaling.
PMID:11399519
STAT1, IRF1 and NF-kB interact with NOS2 promoter and cooperatively activate NOS2 expression in macrophages downstteam of IFNG.
PMID:9864217
IFNG cooperates with TNF and TLR signaling in NF-kB activation.
PMID:18977329
IL-1β activates MDSC in vitro and in vivo through an IL-1RI/NF-κB pathway.
PMID:21826665
NFkB is activated in TANs

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol

NFkB*@INNATE_IMMUNE_CELL_Cytosol

Participates in complexes:

Participates in reactions:
As Reactant or Product:

As Catalyser: